Differences in Regional Brain Activities during Memory Acquisition Depending on Individual Working Memory Capacity

IF 0.8 Q4 ENGINEERING, BIOMEDICAL
H. Gan, Tatsuya Suzuki, K. Yokosawa, Y. Ono
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Abstract

Individual capacity of recall memory varies greatly even among healthy young adults. Nevertheless, the difference in brain circuitry underlying varied memory capacity has yet to be fully investigated. We acquired electroencephalographic measurements from 43 healthy young adults while performing a demanding working memory task and studied the changes in regional cortical activity in relation to different levels of memory performance. The memory task involved sequentially presenting seven arrow pictures to a participant during the encoding period, who was then asked to recall the direction of one of the arrows in the sequence within the retrieval period. We divided the participants into three groups of high, intermediate, and low performance based on the weighted hierarchical grouping method. Regional brain activities were source-localized using multiple sparse priors method in the highand low-performance groups, and group differences were determined by non-parametric permutation tests. Our ndings showed that participants with higher memory performance exhibited wider distribution of cortical activity including the prefrontal and parieto-posterior cortices, whereas lower performance participants only exhibited stable activations across occipital regions. The results implied the importance of selective attention in order to attain optimal individual working memory performance. Furthermore, we suggest the potential role of the angular gyrus as an interplay between the prefrontal and posterior regions for the management of stimulus ow and signal control. Future works should focus on conducting more thorough connectivity analysis to investigate the relationship of cortical activations with individual working memory performance.
个体工作记忆容量对记忆获取过程中脑区域活动的影响
即使在健康的年轻人中,个人回忆记忆的能力也有很大差异。然而,不同记忆容量背后的脑回路差异尚未得到充分研究。我们获得了43名健康年轻人在执行高要求工作记忆任务时的脑电图测量结果,并研究了不同水平记忆表现相关的区域皮层活动的变化。记忆任务包括在编码期间依次向参与者展示七张箭头图片,然后要求参与者在检索期间回忆序列中其中一个箭头的方向。基于加权分层分组法,将参与者分为高、中、低三组。利用多重稀疏先验方法对高、低表现组的脑区域活动进行源定位,并通过非参数排列检验确定组间差异。我们的研究结果表明,记忆表现较高的参与者表现出更广泛的皮层活动分布,包括前额叶和顶-后皮层,而记忆表现较差的参与者仅表现出稳定的枕区激活。研究结果暗示了选择性注意对于获得最佳个人工作记忆表现的重要性。此外,我们认为角回作为前额叶和后部区域之间的相互作用,在管理刺激信号和控制信号方面具有潜在的作用。未来的工作应侧重于进行更深入的连通性分析,以研究皮层激活与个体工作记忆表现的关系。
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来源期刊
Advanced Biomedical Engineering
Advanced Biomedical Engineering ENGINEERING, BIOMEDICAL-
CiteScore
1.40
自引率
10.00%
发文量
15
审稿时长
15 weeks
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