A feokromocitóma – egy különleges endokrin daganat • Pheochromocytoma–A Peculiar Endocrine Tumour

Abstract

Pheochromocytoma is a rare neuroendocrine tumour, which has the highest rate of heritability among all human tumours. It originates predominantly from the adrenal medulla, however approximately 20% of all cases are located extra-adrenally (so called paraganglioma). The catecholamine hormones released from the tumour can lead to diverse clinical manifestations. Pheochromocytoma is a peculiar endocrine tumour characterized by three major aspects. Its high heritability is related to the observation that germline mutations can be detected in about 40% of patients affected by pheochromocytoma. Moreover, somatic mutations can be identified in a big proportion of non-hereditary, sporadic tumours. To date, more than 20 genes