The Effect of the Antioxidant Drug “U-74389G” on Haemoglobin Levels Following a Hypoxemia/ Re-oxygenation Protocol in Rats

IF 0.9 Q4 CRITICAL CARE MEDICINE

Journal of Critical Care Medicine Pub Date : 2015-05-01 DOI:10.1515/jccm-2015-0017

C. Tsompos, C. Panoulis, K. Toutouzas, G. Zografos, A. Papalois

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引用次数: 3

Abstract

Abstract Critically ill patients usually present with circulatory hypoxemia and this is associated with a poorer prognosis. The aim of this experimental study was to examine the effect of U-74389G with specific regard to a hypoxemia/re-oxygenation protocol, on mean blood haemoglobin (Hgb) levels in rats. Materials and methods: Forty rats (mean weight 231.9 g) were used in the study. Hgb levels were measured at sixty minutes (groups A and C) and at 120 minutes (groups B and D) of re-oxygenation. U-74389G was administered only in groups C and D. Results: U-74389G administration non-significantly increased the Hgb levels by 3.95+2.10% (p=0.0604). Re-oxygenation time non-significantly increased the Hgb levels by 3.39+2.12% (p=0.1285). U-74389G administration and reoxygenation time together, significantly increased the Hgb levels by 2.55%+1.25% (p=0.0423). Conclusions: Results of this study indicate that U-74389G administration, re-oxygenation time, but mainly their interaction significantly increase the Hgb levels within the studied time limits.

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抗氧化药物“U-74389G”对大鼠低氧血症/再氧方案后血红蛋白水平的影响

危重患者通常表现为循环低氧血症，这与较差的预后有关。本实验研究的目的是研究U-74389G在低氧血症/再氧合方案下对大鼠平均血红蛋白(Hgb)水平的影响。材料与方法:选用大鼠40只，平均体重231.9 g。测定再氧化60分钟(A、C组)和120分钟(B、D组)Hgb水平。结果:U-74389G组Hgb水平升高3.95+2.10%，无统计学意义(p=0.0604)。复氧时间使Hgb水平无显著性升高3.39+2.12% (p=0.1285)。U-74389G给药与复氧时间共同作用，使Hgb水平显著升高2.55%+1.25% (p=0.0423)。结论:本研究结果表明，在研究时限内，U-74389G给药、复氧时间，但主要是它们的相互作用显著提高了Hgb水平。

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