Lifestyle and Socioeconomic Transition and Health Consequences of Alzheimer's Disease and Other Dementias in Global, from 1990 to 2019.

IF 8.5 3区医学 Q1 CLINICAL NEUROLOGY

Jpad-Journal of Prevention of Alzheimers Disease Pub Date : 2024-01-01 DOI:10.14283/jpad.2023.63

Y Cui, W Yang, J Shuai, Y Ma, Y Yan

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引用次数: 0

Abstract

Background: Previous studies only focused on changes in the global age-specific incidence and mortality for Alzheimer's disease and other dementias, failed to distinguish between cohort and period effects, and did not discuss risk factors separately.

Methods: In this study, Alzheimer's disease disability-adjusted life years (DALYs) data to estimate the burden by gender, age, locations, and social-demographic status for 21 regions from 1990 to 2019. Additionally, trend analysis was performed using the age-period-cohort (APC) model and Join-point model.

Results: In most regions, indicators (incidence, mortality, and DALYs) increased steadily with socio-demographic index(SDI) increased. The age effects for Alzheimer's disease and other dementias showed a significant increase from 40 to 95 years. The cohort effects rate ratios (RRs) had a rapid reduction attributed to smoking, high fasting plasma glucose, and high body mass index (BMI).

Conclusions: Countries in middle-low and low SDI regions have higher levels of risk factor exposure. As a result, rapid and effective government responses are necessary to control dementia risk factors and reduce the disease burden in these countries.

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1990 至 2019 年全球阿尔茨海默病和其他痴呆症的生活方式和社会经济转型及健康后果。

背景：以往的研究只关注阿尔茨海默病和其他痴呆症的全球特定年龄发病率和死亡率的变化，没有区分队列效应和时期效应，也没有单独讨论风险因素：本研究利用阿尔茨海默病残疾调整生命年（DALYs）数据，按性别、年龄、地区和社会人口状况估算了 1990 年至 2019 年 21 个地区的负担。此外，还利用年龄-时期-队列（APC）模型和加入点模型进行了趋势分析：结果：在大多数地区，随着社会人口指数（SDI）的增加，各项指标（发病率、死亡率和残疾调整寿命年数）都在稳步上升。阿尔茨海默病和其他痴呆症的年龄效应显示，从 40 岁到 95 岁的年龄效应显著增加。吸烟、高空腹血浆葡萄糖和高体重指数（BMI）导致队列效应比率（RRs）迅速降低：结论：中低和低 SDI 地区国家的风险因素暴露水平较高。因此，政府有必要采取快速有效的应对措施，控制痴呆症风险因素，减轻这些国家的疾病负担。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Jpad-Journal of Prevention of Alzheimers Disease CLINICAL NEUROLOGY-

自引率

7.80%

发文量

期刊介绍： The JPAD « Journal of Prevention of Alzheimer’Disease » will publish reviews, original research articles and short reports to improve our knowledge in the field of Alzheimer prevention including : neurosciences, biomarkers, imaging, epidemiology, public health, physical cognitive exercise, nutrition, risk and protective factors, drug development, trials design, and heath economic outcomes. JPAD will publish also the meeting abstracts from Clinical Trial on Alzheimer Disease (CTAD) and will be distributed both in paper and online version worldwide.