Improved Melatonin Dissolution Properties: A Way Forward for Treating Children with Sleep Disorders

IF 1 4区医学 Q4 PHARMACOLOGY & PHARMACY

Dissolution Technologies Pub Date : 2023-01-01 DOI:10.14227/dt300223p66

Jeovanis Gil, J. Malm, G. Marko‐Varga

引用次数: 0

Abstract

Sleep problems, in particular the difficulty in initiating and maintaining sleep are important comorbidities in children and adolescents with attention deficit hyperactivity disorder (ADHD), accompanied by a range of negative consequences for both patients and their caregivers. Melatonin, a naturally occurring hormone that is important for coordinating the body's sleep-wake cycle, has been used to treat insomnia in children with ADHD. This study compares the dissolution properties of two melatonin tablets (1 and 5 mg Mellozzan and Melatonin AGB). Results showed that Mellozzan dissolved rapidly (90% within 5 minutes) in all pH levels tested, whereas Melatonin AGB dissolved slower (60% within 30 minutes). The fast dissolution properties of melatonin observed in Mellozzan indicates that this formulation is preferable for the treatment of children where the dissolution step is critical to reach the desired clinical effect.

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改善褪黑激素溶解特性:一种治疗儿童睡眠障碍的方法

睡眠问题，特别是难以开始和维持睡眠是儿童和青少年注意缺陷多动障碍(ADHD)的重要合并症，并伴随一系列对患者及其照顾者的负面影响。褪黑素是一种自然产生的激素，对协调身体的睡眠-觉醒周期很重要，已被用于治疗多动症儿童的失眠。本研究比较了两种褪黑素片(1 mg和5 mg美洛赞和褪黑素AGB)的溶出特性。结果表明，美洛赞在所有测试的pH值下溶解迅速(5分钟内溶解90%)，而褪黑素AGB溶解较慢(30分钟内溶解60%)。在美洛赞中观察到的褪黑素的快速溶解特性表明，这种配方更适合治疗儿童，因为溶解步骤对达到预期的临床效果至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dissolution Technologies 医学-药学

CiteScore

1.20

自引率

33.30%

发文量

审稿时长

3 months

期刊介绍： Dissolution Technologies is a peer reviewed quarterly publication reporting ongoing, useful information on dissolution testing of pharmaceuticals. It provides an international forum for dissolution analysts to receive and exchange information on various dissolution topics. Dissolution Technologies welcomes submissions related to dissolution, in vitro release, and disintegration testing. These topics should be the major focus of the article. Do not submit articles where the focus is formulation development with dissolution testing as one of many tests.