A Data Set to Verify Volume and Sample Removal Correction Calculations for Dissolution Testing

Abstract

Software in the form of a spreadsheet, computer program, or web-based application is typically used to perform the appropriate mathematical corrections to dissolution profile data to correct for the amount of sample solution removed from the dissolution vessels at each time interval. Because the sample solutions contain analyte and because removal changes the volume of dissolution medium remaining in the vessels, such corrections are sometimes necessary to determine accurate values. This article presents results from a mental exercise where a theoretical dissolution profile was constructed. These data can be used to verify the accuracy of such calculations.