The role of long noncoding ribonucleic acids in the central nervous system injury.

IF 3.5 2区生物学 Q3 CELL BIOLOGY

Molecular and Cellular Biochemistry Pub Date : 2024-10-01 Epub Date: 2023-10-28 DOI:10.1007/s11010-023-04875-0

Min Huang, Xizhi Wang, Benson O A Botchway, Yong Zhang, Xuehong Liu

引用次数: 0

Abstract

Central nervous system (CNS) injury involves complex pathophysiological molecular mechanisms. Long noncoding ribonucleic acids (lncRNAs) are an important form of RNA that do not encode proteins but take part in the regulation of gene expression and various biological processes. Multitudinous studies have evidenced lncRNAs to have a significant role in the process of progression and recovery of various CNS injuries. Herein, we review the latest findings pertaining to the role of lncRNAs in CNS, both normal and diseased state. We aim to present a comprehensive clinical application prospect of lncRNAs in CNS, and thus, discuss potential strategies of lncRNAs in treating CNS injury.

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长链非编码核糖核酸在中枢神经系统损伤中的作用。

中枢神经系统损伤涉及复杂的病理生理分子机制。长链非编码核糖核酸（lncRNA）是一种重要的RNA形式，不编码蛋白质，但参与基因表达和各种生物过程的调节。多项研究证明lncRNA在各种中枢神经系统损伤的进展和恢复过程中发挥着重要作用。在此，我们综述了lncRNA在正常和患病状态下中枢神经系统中作用的最新发现。我们的目的是展示lncRNA在中枢神经系统中的全面临床应用前景，从而讨论lncRNA治疗中枢神经系统损伤的潜在策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular and Cellular Biochemistry 生物-细胞生物学

CiteScore

8.30

自引率

2.30%

发文量

293

审稿时长

1.7 months

期刊介绍： Molecular and Cellular Biochemistry: An International Journal for Chemical Biology in Health and Disease publishes original research papers and short communications in all areas of the biochemical sciences, emphasizing novel findings relevant to the biochemical basis of cellular function and disease processes, as well as the mechanics of action of hormones and chemical agents. Coverage includes membrane transport, receptor mechanism, immune response, secretory processes, and cytoskeletal function, as well as biochemical structure-function relationships in the cell. In addition to the reports of original research, the journal publishes state of the art reviews. Specific subjects covered by Molecular and Cellular Biochemistry include cellular metabolism, cellular pathophysiology, enzymology, ion transport, lipid biochemistry, membrane biochemistry, molecular biology, nuclear structure and function, and protein chemistry.