{"title":"Analyzing Large Biological Datasets with an Improved Algorithm for MIC","authors":"Shuliang Wang, Yiping Zhao","doi":"10.1504/IJDMB.2015.071548","DOIUrl":null,"url":null,"abstract":"The computational framework used the traditional similarity measures to find out the significant relationships in biological annotations. But its prerequisites that the biological annotations do not cooccur with each other is particular. To overcome it, in this paper a new method Improved Algorithm for Maximal Information Coefficient (IAMIC) is suggested to discover the hidden regularities between biological annotations. IAMIC approximates a novel similarity coefficient on maximal information coefficient with generality and equitability, by bettering axis partition through quadratic optimisation instead of violence search. The experimental results show that IAMIC is more appropriate for identifying the associations between biological annotations, and further extracting the novel associations hidden in collected data sets than other similarity measures.","PeriodicalId":54964,"journal":{"name":"International Journal of Data Mining and Bioinformatics","volume":"13 2 1","pages":"158-70"},"PeriodicalIF":0.2000,"publicationDate":"2014-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJDMB.2015.071548","citationCount":"10","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Data Mining and Bioinformatics","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1504/IJDMB.2015.071548","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MATHEMATICAL & COMPUTATIONAL BIOLOGY","Score":null,"Total":0}
引用次数: 10
Abstract
The computational framework used the traditional similarity measures to find out the significant relationships in biological annotations. But its prerequisites that the biological annotations do not cooccur with each other is particular. To overcome it, in this paper a new method Improved Algorithm for Maximal Information Coefficient (IAMIC) is suggested to discover the hidden regularities between biological annotations. IAMIC approximates a novel similarity coefficient on maximal information coefficient with generality and equitability, by bettering axis partition through quadratic optimisation instead of violence search. The experimental results show that IAMIC is more appropriate for identifying the associations between biological annotations, and further extracting the novel associations hidden in collected data sets than other similarity measures.
期刊介绍:
Mining bioinformatics data is an emerging area at the intersection between bioinformatics and data mining. The objective of IJDMB is to facilitate collaboration between data mining researchers and bioinformaticians by presenting cutting edge research topics and methodologies in the area of data mining for bioinformatics. This perspective acknowledges the inter-disciplinary nature of research in data mining and bioinformatics and provides a unified forum for researchers/practitioners/students/policy makers to share the latest research and developments in this fast growing multi-disciplinary research area.