Vascular reactivity and metabolism of the reactive forms of oxygen and nitrogen: effects of low doses of radiation

Q4 Medicine

International Journal of Low Radiation Pub Date : 2011-12-21 DOI:10.1504/IJLR.2011.044192

M. N. Tkachenko, Anatolii V. Kotsjuruba, O. Bazilyuk, I. V. Gorot, O. I. Remennik, V. Sagach

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引用次数: 2

Abstract

Endothelium-dependent and endothelium-independent vascular reactions of relaxation, the rate of reactive oxygen species (superoxide and hydroxyl) generation, the content of stable nitric oxide (NO) metabolites (nitrite, nitrate and nitrosothiols), the pools of lipid peroxidation products (eicosanoids LTC 4 and TxB 2 , dienic conjugates and malonic dialdehyde), H 2 O 2 , uric acid and urea were studied in aorta preparations of BALB/c 9 months-old mice: group I – control; group II – exposed to chronic external low doses γ -irradiation (equivalent dose of 96.9 μSv·h –1 ) mice (cumulative dose of 0.43 Sv). The results obtained showed disturbances in the studied reactions and change of the reactive forms of oxygen and nitrogen following an effect of low doses of radiation. The latter induce significant changes in the pools of NO stable metabolites, which can cause disturbances in the NO-dependent physiological functions of heart and aorta. A significant decrease in the levels of nitrite and S-nitrosothiols can...

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血管反应性和氧、氮活性形式的代谢:低剂量辐射的影响

研究了9月龄BALB/c小鼠主动脉制剂中内皮依赖性和内皮非依赖性血管舒张反应、活性氧(超氧化物和羟基)生成速率、稳定型一氧化氮(NO)代谢物(亚硝酸盐、硝酸盐和亚硝基硫醇)含量、脂质过氧化产物(二十烷类ltc4和txb2、二烯偶联物和丙二醛双醛)、h2o2、尿酸和尿素的含量:ⅰ组-对照组;II组-慢性低剂量外源γ照射(等效剂量为96.9 μSv·h - 1)小鼠(累积剂量为0.43 Sv)。得到的结果表明，在低剂量辐射的影响下，所研究的反应受到干扰，氧和氮的活性形式发生了变化。后者引起一氧化氮稳定代谢产物池的显著变化，从而引起心脏和主动脉一氧化氮依赖性生理功能的紊乱。亚硝酸盐和s -亚硝基硫醇含量的显著降低可以…

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来源期刊

International Journal of Low Radiation Environmental Science-Health, Toxicology and Mutagenesis

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期刊介绍： The IJLR is a peer-reviewed journal dedicated to the publication of research articles, review papers and technical notes in all domains related to low-dose radiation, among which are the biological and health effects in humans and the biota, in vitro and in vivo research on low radiation effects, regulatory and policy aspects, risk estimation and public perception.