Flavonoid coated Titanium surfaces for Bioactive Bone implants

Abstract

Flavonoids are small polyphenolic molecules, ubiquitously found in nature, with antioxidant, anti-inflammatory and antibacterial properties. Recently, we presented a bioactive surface based on the covalent grafting of flavonoids taxifolin and quercitrin on titanium substrates. The flavonoid-modified surfaces exhibited interesting biological effects in vitro with two human cell types: they stimulated the differentiation of mesenchymal stem cells from umbilical cord (hUC-MSCs) to osteoblasts, and showed anti-inflammatory and anti-fibrotic potential on gingival fibroblasts (HGF). Hence, these bioactive surfaces could readily have a clinical application in the development of advanced dental implants. Flavonoid compounds are being studied for several therapeutic applications –cancer, cardiovascular, liver, neurodegenerative diseases...-. Therefore, flavonoid-modified biomaterials could be used in numerous biomedical applications.