{"title":"The biological function of microRNA195 and its relationship with angiogenesis","authors":"Jingjing Wang, Q. Zeng, Caihong Yi, Jinjing Luo, Ningning Tang, Shao-Hua Wang, Jia Chen, K. Cao, Jianda Zhou","doi":"10.14800/RD.610","DOIUrl":null,"url":null,"abstract":"MicroRNA participates in multiple biological activities by combining with target genes, degrading target mRNA or suppressing its translation which regulates the expression of genes. MicroRNA-195 is an important member of microRNA-15/161/195/424/497 family. miRNA-195 exerts its significant biological function in regulating cell cycle, apoptosis, cell metabolism, cell proliferation and metastasis by targetedly modulating MYB, CCND1, CCND3, CCNE1, E2F3, CDK6, Bcl-2, APP, BACE1, GLUT, SRC-3, Vav2, and CDC42. Recent studies have shown that miRNA-195 regulates angiogenic factors such as FGF1, VEGF and signaling pathways such as TGF-β1/ Smads and that miRNA-195 participates in the restoration of intima, tumour, the remodling of angiocarpy.","PeriodicalId":90965,"journal":{"name":"RNA & disease (Houston, Tex.)","volume":"2 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2015-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"RNA & disease (Houston, Tex.)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14800/RD.610","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
Abstract
MicroRNA participates in multiple biological activities by combining with target genes, degrading target mRNA or suppressing its translation which regulates the expression of genes. MicroRNA-195 is an important member of microRNA-15/161/195/424/497 family. miRNA-195 exerts its significant biological function in regulating cell cycle, apoptosis, cell metabolism, cell proliferation and metastasis by targetedly modulating MYB, CCND1, CCND3, CCNE1, E2F3, CDK6, Bcl-2, APP, BACE1, GLUT, SRC-3, Vav2, and CDC42. Recent studies have shown that miRNA-195 regulates angiogenic factors such as FGF1, VEGF and signaling pathways such as TGF-β1/ Smads and that miRNA-195 participates in the restoration of intima, tumour, the remodling of angiocarpy.
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