Interleukin-15 (IL-15) Strongly Correlates with Increasing HIV-1 Viremia and Markers of Inflammation.

白血病·淋巴瘤 Pub Date : 2016-11-23 eCollection Date: 2016-01-01 DOI:10.1371/journal.pone.0167091

Sanjay Swaminathan, Ju Qiu, Adam W Rupert, Zonghui Hu, Jeanette Higgins, Robin L Dewar, Randy Stevens, Catherine A Rehm, Julia A Metcalf, Brad T Sherman, Michael W Baseler, H Clifford Lane, Tomozumi Imamichi

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引用次数: 0

Abstract

Objective: IL-15 has been postulated to play an important role in HIV-1 infection, yet there are conflicting reports regarding its expression levels in these patients. We sought to measure the level of IL-15 in a large, well characterised cohort of HIV-1 infected patients and correlate this with well known markers of inflammation, including CRP, D-dimer, sCD163 and sCD14.

Design and methods: IL-15 levels were measured in 501 people (460 patients with HIV-1 infection and 41 uninfected controls). The HIV-1 infected patients were divided into 4 groups based on viral load: <50 copies/ml, 51-10,000 copies/ml, 10,001-100,000 copies/ml and >100,000 copies/ml. The Mann Whitney test (non-parametric) was used to identify significant relationships between different patient groups.

Results: IL-15 levels were significantly higher in patients with viral loads >100,000 copies/ml (3.02 ± 1.53 pg/ml) compared to both uninfected controls (1.69 ± 0.37 pg/ml, p<0.001) or patients with a viral load <50 copies/ml (1.59 ± 0.40 pg/ml (p<0.001). There was a significant correlation between HIV-1 viremia and IL-15 levels (Spearman r = 0.54, p<0.001) and between CD4+ T cell counts and IL-15 levels (Spearman r = -0.56, p<0.001).

Conclusions: IL-15 levels are significantly elevated in HIV-1 infected patients with viral loads >100,000 copies/ml compared to uninfected controls, with a significant direct correlation noted between IL-15 and HIV-1 viremia and an inverse correlation between IL-15 levels and CD4+ T cell counts. These data support a potential role for IL-15 in the pathogenesis of HIV-associated immune activation.

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白细胞介素-15 (IL-15) 与 HIV-1 病毒血症和炎症标志物的增加密切相关。

目的：据推测，IL-15 在 HIV-1 感染中起着重要作用，但有关其在这些患者中的表达水平的报道却相互矛盾。我们试图测量一大批特征明确的 HIV-1 感染者体内 IL-15 的水平，并将其与 CRP、D-二聚体、sCD163 和 sCD14 等已知炎症指标相关联：对 501 人（460 名 HIV-1 感染者和 41 名未感染者对照组）的 IL-15 水平进行了测量。根据病毒载量将 HIV-1 感染者分为 4 组：100,000 拷贝/毫升。采用曼-惠特尼检验（非参数）确定不同患者组之间的显著关系：结果：与未感染对照组（1.69 ± 0.37 pg/ml，p）相比，病毒载量大于 100,000 拷贝/毫升的患者 IL-15 水平明显更高（3.02 ± 1.53 pg/ml）：与未感染对照组相比，病毒载量大于 100,000 拷贝/毫升的 HIV-1 感染者 IL-15 水平明显升高，IL-15 与 HIV-1 病毒血症之间存在明显的直接相关性，而 IL-15 水平与 CD4+ T 细胞计数之间存在反相关性。这些数据支持了IL-15在HIV相关免疫激活发病机制中的潜在作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

白血病·淋巴瘤 Medicine-Oncology

自引率

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发文量

6278

期刊介绍： The JLL is a specialized academic journal that carries articles on hematological malignancies, and mainly about leukemia and lymphoma, involving the fields of medicine, chemistry, biology, etc. The purposes are to reflect the scientific results and the academic trends in the hematological malignancy field. It paid attention on both the basic research and clinical work, but more on the clinical side; on combining popularization with the raising of standards, but more on the raising of standards, in order to provide a field for exchanging experience, inspiring mutually and linking up information for those working for the basic research and clinical diagnosis and treatment in the field of leukemia and lymphoma. It is intended for high and middle ranking medical staffs.