Hypocholesterolemic Effect of Lactococcus lactis subsp. lactis biovar diacetylactis N7 and Lactococcus lactis subsp. lactis 527 Strains in SD Rats

Abstract

The effect of Lactococcus lactis subsp. lactis biovar diacetylactis N7 (LACC-N7) and Lactococcus lactis subsp. lactis 527 (LACC-527) strains isolated from dairy products on serum cholesterol levels in the SD rats were investigated. The administration of LACC-N7 significantly decreased total serum cholesterol (p<0.001) and triglycerides (p<0.05) and increased HDL-cholesterol ratio to total cholesterol (p<0.05) at 6 weeks post-administration. LACC-527 had an effect on total serum cholesterol (p<0.05) and HDL-cholesterol ratio to total cholesterol (p<0.05) at 6 weeks and triglycerides (p<0.01) at 4 weeks post-administration. Enterococcus faecium (ENT-1) also significantly decreased total serum cholesterol (p<0.001), and increased the HDL-cholesterol ratio to total cholesterol (p<0.05). These results suggest that LACC-N7 and LACC-527 would be effective as probiotics for the prevention of hypercholesterolemia and fatty liver.