Pathological analysis of lesions in the exocrine pancreas of rats induced by Zinc Maltol.

IF 0.9 4区医学 Q4 PATHOLOGY

Journal of Toxicologic Pathology Pub Date : 2023-10-01 Epub Date: 2023-07-13 DOI:10.1293/tox.2023-0063

FujiwaraSakura, MorokiTakayasu, HitomiMasaya, SatoMakoto, TerayamaYui, YoshikawaTsuyoshi

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Abstract

The pancreas plays an important role in the homeostasis of zinc (Zn), a nutritionally essential metal. In several previous studies, Zn ions induced inflammatory changes in the exocrine pancreas; however, little is known about Zn complexes. In this study, we microscopically, immunohistochemically, and ultrastructurally examined pancreatic lesions in Sprague-Dawley (SD) rats induced by a 4-week repeated oral dose toxicity study of Zinc Maltol (ZM), a zinc (II) complex. ZM induces acinar atrophy and increases the number of duct-like structures. Immunohistochemistry revealed a decrease in the number of trypsin-positive cells, and an increase in the number of SOX9-positive cells. Interstitial fibrosis and macrophage infiltration also correlated with the degree of acinar atrophy. Electron microscopic evaluation revealed that the acinar cells that lost granules were surrounded by fibroblasts and collagen fibers. In conclusion, we provided a detailed description of ZM-induced pancreatic lesions in SD rats.

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麦芽酚锌致大鼠外分泌胰腺损伤的病理学分析。

胰腺在锌（一种营养必需金属）的稳态中起着重要作用。在之前的几项研究中，锌离子诱导胰腺外分泌的炎症变化；然而，对锌配合物知之甚少。在本研究中，我们对Sprague-Dawley（SD）大鼠的胰腺损伤进行了显微镜、免疫组织化学和超微结构检查，该损伤是由锌（II）复合物锌麦芽酚（ZM）的4周重复口服剂量毒性研究引起的。ZM诱导腺泡萎缩并增加导管样结构的数量。免疫组织化学显示胰蛋白酶阳性细胞数量减少，SOX9阳性细胞数量增加。间质纤维化和巨噬细胞浸润也与腺泡萎缩的程度相关。电镜评估显示，失去颗粒的腺泡细胞被成纤维细胞和胶原纤维包围。总之，我们提供了ZM诱导SD大鼠胰腺病变的详细描述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Toxicologic Pathology PATHOLOGY-TOXICOLOGY

CiteScore

2.10

自引率

16.70%

发文量

审稿时长

>12 weeks

期刊介绍： JTP is a scientific journal that publishes original studies in the field of toxicological pathology and in a wide variety of other related fields. The main scope of the journal is listed below. Administrative Opinions of Policymakers and Regulatory Agencies Adverse Events Carcinogenesis Data of A Predominantly Negative Nature Drug-Induced Hematologic Toxicity Embryological Pathology High Throughput Pathology Historical Data of Experimental Animals Immunohistochemical Analysis Molecular Pathology Nomenclature of Lesions Non-mammal Toxicity Study Result or Lesion Induced by Chemicals of Which Names Hidden on Account of the Authors Technology and Methodology Related to Toxicological Pathology Tumor Pathology; Neoplasia and Hyperplasia Ultrastructural Analysis Use of Animal Models.