{"title":"Histopathology of fused triplet placenta in rat.","authors":"FurukawaSatoshi, TsujiNaho, HayashiSeigo, KurodaYusuke, KimuraMasayuki, KojimaChisato, TakeuchiKazuya","doi":"10.1293/tox.2023-0026","DOIUrl":null,"url":null,"abstract":"<p><p>A fused triplet placenta was observed in a Wistar Hannover rat on gestation day 15. Each placenta (referred to as PL-A, PL-B, and PL-C) of this fused placenta was attached to one fetus each, but their fetal weights were lower than that of the fetus attached to the only normal placenta (referred to as PL-N) in this dam. Histopathologically, thinning of the trophoblastic septa and dilatation of the maternal sinusoid in the labyrinth zone were observed in PL-B and PL-C, but not in PL-A or PL-N. The points of placental fusion were at the junctional zone derived from each side of the placenta without connective tissues, and the septum was composed of trophoblastic giant cells. Although PL-A had a solitary metrial gland, PL-B and PL-C shared one metrial gland with one spiral artery terminus branching towards each labyrinth zone.</p>","PeriodicalId":17437,"journal":{"name":"Journal of Toxicologic Pathology","volume":null,"pages":null},"PeriodicalIF":0.9000,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10585243/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Toxicologic Pathology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1293/tox.2023-0026","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/6/5 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"PATHOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
A fused triplet placenta was observed in a Wistar Hannover rat on gestation day 15. Each placenta (referred to as PL-A, PL-B, and PL-C) of this fused placenta was attached to one fetus each, but their fetal weights were lower than that of the fetus attached to the only normal placenta (referred to as PL-N) in this dam. Histopathologically, thinning of the trophoblastic septa and dilatation of the maternal sinusoid in the labyrinth zone were observed in PL-B and PL-C, but not in PL-A or PL-N. The points of placental fusion were at the junctional zone derived from each side of the placenta without connective tissues, and the septum was composed of trophoblastic giant cells. Although PL-A had a solitary metrial gland, PL-B and PL-C shared one metrial gland with one spiral artery terminus branching towards each labyrinth zone.
期刊介绍：
JTP is a scientific journal that publishes original studies in the field of toxicological pathology and in a wide variety of other related fields. The main scope of the journal is listed below.
Administrative Opinions of Policymakers and Regulatory Agencies
Adverse Events
Carcinogenesis
Data of A Predominantly Negative Nature
Drug-Induced Hematologic Toxicity
Embryological Pathology
High Throughput Pathology
Historical Data of Experimental Animals
Immunohistochemical Analysis
Molecular Pathology
Nomenclature of Lesions
Non-mammal Toxicity Study
Result or Lesion Induced by Chemicals of Which Names Hidden on Account of the Authors
Technology and Methodology Related to Toxicological Pathology
Tumor Pathology; Neoplasia and Hyperplasia
Ultrastructural Analysis
Use of Animal Models.
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