Deep vein thrombosis resolution, recurrence and post-thrombotic syndrome: a prospective observational study protocol.

Q2 Medicine

BMC Hematology Pub Date : 2016-09-15 eCollection Date: 2016-01-01 DOI:10.1186/s12878-016-0063-7

M Bonfield, F Cramp, J Pollock

{"title":"Deep vein thrombosis resolution, recurrence and post-thrombotic syndrome: a prospective observational study protocol.","authors":"M Bonfield, F Cramp, J Pollock","doi":"10.1186/s12878-016-0063-7","DOIUrl":null,"url":null,"abstract":"Background: Reasons for the variation in response of deep vein thrombosis (DVT) to anticoagulation treatment are not known. Some patients develop complications such as post-thrombotic syndrome or recurrent DVT but others make a full recovery. The aim of the study is to identify the level of variation in response to anticoagulation treatment and provide more precise and quantitative disease characterisation in response to treatment.Methods: A prospective observational study using duplex ultrasound to examine changes in thrombus characterisation, evolution and resolution over a 2 year period in patients with a confirmed DVT. Logistic regression analysis will be used to seek associations between characteristics present at baseline and the outcomes of DVT resolution, recurrence and the development of post-thrombotic syndrome (PTS).Discussion: This research into the response to treatment of lower limb DVT and predictive factors for DVT resolution, recurrence and PTS could inform a more tailored approach to anticoagulation therapy for the future management of DVT.Ukcrn id: 16016. Registered on 20 January 2014.","PeriodicalId":37740,"journal":{"name":"BMC Hematology","volume":"16 1","pages":"24"},"PeriodicalIF":0.0000,"publicationDate":"2016-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025593/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Hematology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s12878-016-0063-7","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2016/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Reasons for the variation in response of deep vein thrombosis (DVT) to anticoagulation treatment are not known. Some patients develop complications such as post-thrombotic syndrome or recurrent DVT but others make a full recovery. The aim of the study is to identify the level of variation in response to anticoagulation treatment and provide more precise and quantitative disease characterisation in response to treatment.

Methods: A prospective observational study using duplex ultrasound to examine changes in thrombus characterisation, evolution and resolution over a 2 year period in patients with a confirmed DVT. Logistic regression analysis will be used to seek associations between characteristics present at baseline and the outcomes of DVT resolution, recurrence and the development of post-thrombotic syndrome (PTS).

Discussion: This research into the response to treatment of lower limb DVT and predictive factors for DVT resolution, recurrence and PTS could inform a more tailored approach to anticoagulation therapy for the future management of DVT.

Ukcrn id: 16016. Registered on 20 January 2014.

查看原文本刊更多论文

深静脉血栓消退、复发和血栓形成后综合征：一项前瞻性观察性研究方案。

背景：深静脉血栓（DVT）抗凝治疗反应变化的原因尚不清楚。一些患者出现并发症，如血栓形成后综合征或复发性深静脉血栓，但其他患者完全康复。该研究的目的是确定抗凝治疗反应的变化水平，并提供更精确和定量的疾病特征。方法：一项前瞻性观察研究，使用双相超声检查确诊深静脉血栓患者2年内血栓特征、演变和消退的变化。Logistic回归分析将用于寻找基线特征与深静脉血栓消退、复发和血栓后综合征（PTS）发展之间的关联。讨论：这项研究对下肢DVT治疗的反应以及DVT消退、复发和PTS的预测因素可以为未来DVT的治疗提供更有针对性的抗凝治疗方法。乌克兰id: 16016。注册于2014年1月20日。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

BMC Hematology Medicine-Hematology

CiteScore

4.10

自引率

0.00%

发文量

期刊介绍： BMC Hematology is an open access, peer-reviewed journal that considers articles on basic, experimental and clinical research related to hematology. The journal welcomes submissions on non-malignant and malignant hematological diseases, hemostasis and thrombosis, hematopoiesis, stem cells and transplantation.