Evaluation of the Antiulcer Activity of the Leaves of Azadirachta indica: An Experimental Study

Integrative medicine international Pub Date : 2016-01-14 DOI:10.1159/000442750

P. Bhajoni, G. Meshram, M. Lahkar

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引用次数: 29

Abstract

Background:Azadirachta indica, an evergreen tree, is used by several folkloric practitioners to treat peptic ulcers in India. The present study was carried out to evaluate the antiulcer activity of the aqueous extract (AE) of the leaves of A. indica in Wistar rats. Methods: Gastric ulcerations were induced by pyloric ligation, aspirin, and cold restraint stress. AE was used in doses of 150, 300, and 600 mg/kg body weight per os. Distilled water served as the control and ranitidine 20 mg/kg body weight intraperitoneal as the reference standard. The ulcer index (UI) and percentage inhibition (PI) values were determined in each model. The volume of gastric contents, free acidity, total acidity, and pH were measured in the pyloric ligation-induced ulcer model. Results: AE showed a dose-dependent and significant (p < 0.05) decrease in the UI and an increase in the PI in all models employed compared to the control group. AE caused a dose-dependent decline in the gastric content volume, free acidity, and total acidity. Conclusion: The leaves of A. indica possess significant antiulcer activity and act via multiple mechanisms.

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印楝叶抗溃疡活性的实验研究

背景:印楝是一种常青树，在印度被一些民间从业者用来治疗消化性溃疡。本研究旨在评价印楝叶水提物(AE)对Wistar大鼠的抗溃疡活性。方法:采用幽门结扎、阿斯匹林、冷约束应激诱导胃溃疡。AE的剂量分别为150、300和600 mg/kg体重。以蒸馏水为对照，雷尼替丁20 mg/kg体重腹腔注射为参比标准。测定各模型的溃疡指数(UI)和百分比抑制(PI)值。测定幽门结扎性溃疡模型胃内容物体积、游离酸度、总酸度及pH值。结果:与对照组相比，AE在所有模型中均呈剂量依赖性，显著降低UI (p < 0.05)，增加PI (p < 0.05)。AE引起胃内容物体积、游离酸度和总酸度呈剂量依赖性下降。结论:印楝叶具有明显的抗溃疡活性，其作用机制多种多样。

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Integrative medicine international

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