Archaeal MCM Proteins as an Analog for the Eukaryotic Mcm2–7 Helicase to Reveal Essential Features of Structure and Function

IF 2.3 4区 生物学 Q3 MICROBIOLOGY
Justin M. Miller, E. J. Enemark
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引用次数: 21

Abstract

In eukaryotes, the replicative helicase is the large multisubunit CMG complex consisting of the Mcm2–7 hexameric ring, Cdc45, and the tetrameric GINS complex. The Mcm2–7 ring assembles from six different, related proteins and forms the core of this complex. In archaea, a homologous MCM hexameric ring functions as the replicative helicase at the replication fork. Archaeal MCM proteins form thermostable homohexamers, facilitating their use as models of the eukaryotic Mcm2–7 helicase. Here we review archaeal MCM helicase structure and function and how the archaeal findings relate to the eukaryotic Mcm2–7 ring.
古细菌MCM蛋白作为真核Mcm2-7解旋酶的类似物揭示其结构和功能的基本特征
在真核生物中,复制解旋酶是由Mcm2-7六聚体环、Cdc45和四聚体GINS复合物组成的大型多亚基CMG复合物。Mcm2-7环由六种不同的相关蛋白质组合而成,形成了这个复合物的核心。在古细菌中,同源的MCM六聚体环在复制叉上起着复制解旋酶的作用。古细菌MCM蛋白形成耐热的同六聚体,便于它们作为真核Mcm2-7解旋酶的模型。本文综述了古细菌MCM解旋酶的结构和功能,以及这些发现与真核生物Mcm2-7环的关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.50
自引率
0.00%
发文量
1
审稿时长
>12 weeks
期刊介绍: Archaea is a peer-reviewed, Open Access journal that publishes original research articles as well as review articles dealing with all aspects of archaea, including environmental adaptation, enzymology, genetics and genomics, metabolism, molecular biology, molecular ecology, phylogeny, and ultrastructure. Bioinformatics studies and biotechnological implications of archaea will be considered. Published since 2002, Archaea provides a unique venue for exchanging information about these extraordinary prokaryotes.
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