Utility of Activated Glassy Carbon and Pencil Graphite Electrodes for Voltammetric Determination of Nalbuphine Hydrochloride in Pharmaceutical and Biological Fluids

IF 2.3 Q3 ELECTROCHEMISTRY
H. Elqudaby, H. Hendawy, E. Souaya, G. Mohamed, Ghada M. G. Eldin
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引用次数: 14

Abstract

This work compares voltammetric response of nalbuphine hydrochloride (NP·HCl) at both activated glassy carbon and pencil graphite electrodes. The electrochemical oxidation of the drug was studied using cyclic voltammetry (CV), differential pulse voltammetry (DPV), and square wave voltammetry (SWV) techniques. For analytical purpose a well-resolved irreversible diffusion controlled voltammetric peak was established in Britton-Robinson (B-R) buffer solution of pH 6.00 using pencil graphite electrode (PGE). Using activated glassy carbon electrode (GCE) a well-resolved irreversible diffusion controlled voltammetric peak was obtained at pH 7.00 using the same buffer solution. According to the linear relationship between the peak current and NP·HCl concentration, DPV and SWV methods were developed for their quantitative determination in pharmaceutical and human biological fluids. The linear response was obtained in the range from to mol L−1 using PGE and from to mol L−1 using a GC electrode, respectively. Precision and accuracy of the developed method were checked by recovery studies.
活性炭和铅笔石墨电极伏安法测定制药和生物液中盐酸纳布啡的应用
本研究比较了盐酸纳布啡(NP·HCl)在活性炭和铅笔石墨电极上的伏安响应。采用循环伏安法(CV)、差分脉冲伏安法(DPV)和方波伏安法(SWV)研究了该药物的电化学氧化过程。采用铅笔石墨电极(PGE)在pH为6.00的布里顿-罗宾逊(B-R)缓冲溶液中建立了一个分辨良好的不可逆扩散控制伏安峰。使用相同的缓冲溶液,在pH为7.00时,用活性炭电极(GCE)获得了一个分辨良好的不可逆扩散控制伏安峰。根据峰值电流与NP·HCl浓度之间的线性关系,建立了DPV法和SWV法在制药和人体生物液中的定量测定。PGE法和GC电极法分别在~ mol L−1和~ mol L−1范围内得到了线性响应。通过回收率研究验证了该方法的精密度和准确度。
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