Risk of Malignant Neoplasm in Patients with Incident Rheumatoid Arthritis 1980–2007 in relation to a Comparator Cohort: A Population-Based Study

IF 2.3 Q2 RHEUMATOLOGY
Shafay Raheel, C. Crowson, K. Wright, E. Matteson
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引用次数: 13

Abstract

Objective. To determine whether the incidence of malignancy is increased in patients with rheumatoid arthritis (RA) compared to a matched comparison cohort and to identify risk for any individual malignancy in RA. Methods. A cohort of 813 Olmsted County, Minnesota, residents who first fulfilled 1987 ACR criteria for RA in 1980–2007 was previously identified by medical record review. Medical records of 813 RA cases and a comparison cohort of age and sex matched Olmsted County residents without RA were evaluated retrospectively for cancer occurrence. Patients in both cohorts were followed until death, migration from Olmsted County, or 12/31/2014. Results. The RA and non-RA cohorts (mean age at incidence/index date: 55.9 [SD: 15.7] years; 68.4% females in both cohorts) were followed on average of 14.1 (SD: 7.7) and 14.9 (SD: 8.1) years, respectively. Prior to RA incidence/index date, 52 RA patients and 66 non-RA subjects had malignancies excluding NMSC (p = 0.21). During follow-up, significantly more malignancies occurred in patients with RA (n = 143) than in comparator subjects (n = 118; hazard ratio: 1.32; p = 0.027). Inclusion of NMSC obviated this difference. Conclusion. After excluding NMSC, there was a small to moderately increased risk of malignancies in patients with RA. Cancer surveillance is imperative in all patients with RA.
1980-2007年类风湿关节炎患者发生恶性肿瘤的风险:一项基于人群的研究
目标。确定类风湿关节炎(RA)患者的恶性肿瘤发生率是否比匹配的对照队列增加,并确定类风湿关节炎中任何个体恶性肿瘤的风险。方法。在1980-2007年期间,明尼苏达州奥姆斯特德县的813名居民首次满足1987年ACR标准的RA,先前通过医疗记录审查确定。回顾性评价813例RA病例的医疗记录以及年龄和性别匹配的奥姆斯特德县非RA居民的癌症发生情况。两组患者均被随访至死亡、从奥姆斯特德县迁移或2014年12月31日。结果。RA和非RA组(发病/指数日期时的平均年龄:55.9 [SD: 15.7]岁;随访时间分别为14.1年(SD: 7.7)和14.9年(SD: 8.1)。在RA发病/指数日期之前,52名RA患者和66名非RA受试者除NMSC外患有恶性肿瘤(p = 0.21)。在随访期间,RA患者(n = 143)的恶性肿瘤发生率明显高于对照组(n = 118;风险比:1.32;P = 0.027)。纳入NMSC消除了这种差异。结论。排除NMSC后,RA患者发生恶性肿瘤的风险有小到中等程度的增加。所有类风湿性关节炎患者都必须进行癌症监测。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.40
自引率
0.00%
发文量
9
审稿时长
24 weeks
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