Synthesis of Substituted 3,4-Dialkyl-2,6-Diaryl- Piperidin-4-ol Derivatives and Their Conformational Study

Abstract

The synthesis of series of 3,4-dialkyl-2,6-diaryl-piperidin-4-ol derivatives (7-12) by reduction of cis-3-alkyl-2,6-diarylpiperidin-4-one (1-6) using Grignard reagent has been reported. The synthesized heterocycles have been characterized on basis of spectroscopic data and their conformation has also been discussed.