In Vitro Antioxidant and Cytotoxic Activities of Some Marine Sponges Collected off Misamis Oriental Coast, Philippines

A. Rivera, M. Uy
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引用次数: 17

Abstract

The phosphomolybdenum method for total antioxidant activity determination showed that the hexane, dichloromethane and ethyl acetate extracts of five marine sponge species collected off misamis oriental coast-Aaptos suberitoides, Dactylospongia elegans, Stylissa massa, Haliclona sp. and an unidentified species coded as KL-05, have varying degrees of antioxidant capacity. Expressed as ascorbic acid equivalents in μg/mL of extract, the hexane extract of Dactylospongia elegans (DeH) and the ethyl acetate extract of Aaptos suberitoides (AsE) showed the highest antioxidant capacity. Although the hexane extract of KL-05 (KL-05H) has considerable antioxidant activity, the ethyl acetate extract (KL-05E) showed no antioxidant activity. The brine shrimp assay for cytotoxicity indicated high bioactivity, with Haliclona sp., Dactylospongia elegans, Aaptos suberitoides and Stylissa massa exhibiting high % mortality and low LC50 values. The antioxidant and cytotoxic activities of the marine sponges may be attributed to the zoochemicals present. All sponge species contain alkaloids, saponins, tannins, and flavonoids. Terpenoids are present only in Haliclona sp. and the cardiac glycosides, only in Aaptos suberitoides and Haliclona sp.
菲律宾Misamis东岸某些海洋海绵的体外抗氧化和细胞毒活性
磷钼法测定总抗氧化活性的结果表明,采自日本东岸的5种海绵(aaptos subellioides、Dactylospongia elegans、Stylissa massa、Haliclona sp.和一种编号为KL-05的未确定品种)的己烷、二氯甲烷和乙酸乙酯提取物均具有不同程度的抗氧化能力。以抗坏血酸当量(μg/mL)为单位表示,长叶线虫(dactylolospongia elegans, DeH)的己烷提取物和亚种线虫(Aaptos subsuboides, AsE)的乙酸乙酯提取物的抗氧化能力最强。虽然KL-05的己烷提取物(KL-05H)具有较强的抗氧化活性,但乙酸乙酯提取物(KL-05E)没有抗氧化活性。盐水虾细胞毒性实验显示其生物活性较高,其中海螺(Haliclona sp.)、elegans Dactylospongia Dactylospongia elegans、Aaptos subritoides和柱头花(Stylissa massa)的死亡率较高,LC50值较低。海洋海绵的抗氧化和细胞毒活性可能归因于其中的动物化学物质。所有海绵物种都含有生物碱、皂苷、单宁和类黄酮。萜类化合物仅存在于海苔属和心糖苷中,仅存在于亚亚海苔属和海苔属中。
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来源期刊
E-journal of Chemistry
E-journal of Chemistry CHEMISTRY, MULTIDISCIPLINARY-
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