Screening for Hypoglycemic Activity on The Leaf Extracts of Nine Medicinal Plants: In-Vivo Evaluation

A. Arya, M. Abdullah, Batoul Sadat
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引用次数: 36

Abstract

The traditional use of certain plants by the tribal community in central India involves using the young leaves for several ailments, including hyperglycaemia; this study was performed to evaluate the effects of the leaf extracts from 9 such plants in the management of diabetes. Initially, hypoglycemic screening was performed on normal rats whose blood glucose levels were measured before and after oral or intraperitoneal (i.p.) administration of the extracts at different periods. The plants were screened at doses of 250 mg/kg i.p. or 500 mg/kg orally. Of these, only Centratherum anthelminticum (Asteraceae), Cissus quadrangularis (Vitaceae), and Woodfordia fruticosa Kurz (Lythraceae) significantly reduced postprandial blood glucose levels in normal glycemic rats (P <0.001), with slight reductions effected by Sida acuta Burm F. (P = 0.002) and Parthenium hysterophorus L. (P = 0.017). The extracts that reduced postprandial blood glucose levels both orally and i.p. in the hypoglycemic screening tests were evaluated for glucose challenge in glucose tolerance tests with i.p and oral administration in overnight-fasted normal rats. The results of these tests potentiate the screening data in the management of diabetes mellitus, which requires further studies on the plants that yielded positive results to determine the active compounds in the different plant parts that are responsible for the activity.
九种药用植物叶片提取物降血糖活性的筛选:体内评价
印度中部部落社区对某些植物的传统使用包括用嫩叶治疗几种疾病,包括高血糖;本研究评估了9种此类植物叶片提取物在糖尿病治疗中的作用。首先,对正常大鼠进行低血糖筛查,在不同时期口服或腹腔给药前后测量血糖水平。筛选剂量分别为250 mg/kg和500 mg/kg。其中,只有紫菀(Asteraceae)、猕猴桃(quissus quadrangularis)和木fordia fruticosa Kurz (Lythraceae)能显著降低正常血糖大鼠的餐后血糖水平(P <0.001),而Sida acuta Burm F. (P = 0.002)和Parthenium hysterophorus L. (P = 0.017)有轻微的降低作用。在空腹过夜的正常大鼠的糖耐量试验中,通过口服和口服给药来评估在降糖筛选试验中口服和口服降低餐后血糖水平的提取物对葡萄糖的影响。这些试验的结果增强了糖尿病管理的筛选数据,这需要对产生阳性结果的植物进行进一步的研究,以确定不同植物部位中负责活性的活性化合物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
E-journal of Chemistry
E-journal of Chemistry CHEMISTRY, MULTIDISCIPLINARY-
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