Study of indole inhibitors to increase the affinity of hnps-PLA2 in inflammatory disease

Abstract

There are many Drug used in the treatment of inflammation disease like NSAIDS but there limitation encouraging more research in inflammatory related diseases. Phospholipases A2 (PLA2s) are enzymes that catalyze the hydrolysis of the sn-2 acyl ester linkage of phospholipids, producing fatty acids and lysophospholipids. Their enzymatic activity is a rate-limiting step in the formation of arachidonic acid and subsequently in the synthesis of leukotrienes and prostaglandins. The current Structure Based Drug Designing approach analysis and comparative docking studies of various hnps-PLA2 indole inhibitor derivatives have shown that they act better in compare with other molecules. ADME studies shows that indole derivatives would be potential of being a safe drug