In vitro antimicrobial activity of common species of seaweeds native to Trinidadian coasts

Algological studies (Stuttgart, Germany : 2007) Pub Date : 2015-03-01 DOI:10.1127/ALGOL_STUD/2014/0184

A. Ramkissoon, A. Ramsubhag, A. Maxwell, J. Jayaraman

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引用次数: 1

Abstract

Marine macrophytes have been recently recognized as promising sources of bioactive molecules and as such many drugs leads have arisen from them. We investigated the antibacterial activity of methanol extracts of seaweeds against several human pathogens. Among the seaweeds screened, three species showed inhibitory effects against at least one pathogen, with Ulva fasciata and Amphiroa rigida exhibiting bacteriostatic activity and Chaetomorpha crassa showing bactericidal action against pathogenic Gram-positive cocci. Further testing revealed that the extracts of Chaetomorpha crassa displayed the ability to inhibit biofilm formation and virulence gene expression in Methicillin resistant Staphylococcus aureus (MRSA). Isolation and identification of the bioactive molecules of Chaetomorpha crassa revealed the two free fatty acids stearic acid and linolenic acid. This research shows that several species of marine plants found in Trinidad comprise bioactive compounds and may be good candidates for further investigations aimed at isolating and evaluating these compounds for potential medical applications.

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特立尼达海岸常见海藻的体外抗菌活性研究

近年来，海洋大型植物被认为是生物活性分子的有前途的来源，许多药物的线索都是从它们中产生的。研究了海藻甲醇提取物对几种人体病原菌的抑菌活性。在筛选的海藻中，有3种对至少一种病原菌有抑制作用，其中筋膜藻和硬角藻对致病性革兰氏阳性球菌有抑菌作用，粗毛藻对致病性革兰氏阳性球菌有杀菌作用。进一步的实验表明，毛茛提取物具有抑制耐甲氧西林金黄色葡萄球菌(MRSA)生物膜形成和毒力基因表达的能力。对粗毛毛藻的活性分子进行分离鉴定，发现其游离脂肪酸为硬脂酸和亚麻酸。这项研究表明，在特立尼达发现的几种海洋植物含有生物活性化合物，可能是进一步研究的良好候选者，旨在分离和评估这些化合物的潜在医疗应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Algological studies (Stuttgart, Germany : 2007)

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