In Vitro Antimicrobial Activity of Phosphate-Based Zinc Nanoparticles

Abstract

In recent years, zinc nanoparticles have captivated an attention due to their antimicrobial properties. Moreover, the advantage of nanomaterials is an ability to modify their chemical composition and influence their antibacterial properties. In this study, zinc-phosphate nanoparticles (ZnNPs) were prepared via chemical route of synthesis. Their antibacterial activity was evaluated by monitoring a bacterial growth of model microorganisms: gram-negative (G - ) E. coli , and gram-positive (G + ) S. aureus as well as methicillin-resistant S. aureus (MRSA). Obtained results have shown, the ZnNPs are the most effective against G + S. aureus compared to MRSA or G - E. coli . The inhibition concentrations for S. aureus , E. coli and MRSA was 0.16, 1.25, 2.5 mM, respectively. To conclude, ZnNPs exhibit antibacterial activity against both G + and G - model microorganisms, however, G - bacteria are more sensitive against ZnNPs.