G. Préfontaine, Martin Darveau, C. Ahnadi, P. Lachance, O. Lesur, Christine Drouin, P. Lamarre, C. Vézina
{"title":"Reticulocyte hemoglobin content in 13 critically ill patients: a preliminary study","authors":"G. Préfontaine, Martin Darveau, C. Ahnadi, P. Lachance, O. Lesur, Christine Drouin, P. Lamarre, C. Vézina","doi":"10.1111/J.1778-428X.2009.00123.X","DOIUrl":null,"url":null,"abstract":"SUMMARY In the presence of inflammation, iron availability for erythropoiesis is decreased, and hemoglobin production is reduced in reticulocytes. The reticulocyte hemoglobin content (CHr) provides a real picture of bone marrow status and could be useful to evaluate iron metabolism in critically ill patients. We conducted a preliminary study to evaluate the feasibility to measure the CHr in the intensive care units of two university hospitals and to evaluate the impact of C-reactive protein on CHr values. The CHr was measured in 14 consecutive critically ill patients hospitalized in the intensive care unit between 48 and 96 hours. One patient with a ferritin concentration < 100 mg/L was excluded to eliminate a possible coexistence of iron deficiency with inflammation. A statistically signifi- cant correlation was observed between C-reactive protein concentrations and CHr values (r =- 0.588; P = 0.03, n = 13). The results observed in this preliminary study are interesting and could be useful to establish the research protocol for a future study evaluating iron metabolism in criti- cally ill patients. A larger study is feasible and warranted given the results observed in this preliminary study.","PeriodicalId":90375,"journal":{"name":"Transfusion alternatives in transfusion medicine : TATM","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2008-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/J.1778-428X.2009.00123.X","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Transfusion alternatives in transfusion medicine : TATM","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1111/J.1778-428X.2009.00123.X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 4
Abstract
SUMMARY In the presence of inflammation, iron availability for erythropoiesis is decreased, and hemoglobin production is reduced in reticulocytes. The reticulocyte hemoglobin content (CHr) provides a real picture of bone marrow status and could be useful to evaluate iron metabolism in critically ill patients. We conducted a preliminary study to evaluate the feasibility to measure the CHr in the intensive care units of two university hospitals and to evaluate the impact of C-reactive protein on CHr values. The CHr was measured in 14 consecutive critically ill patients hospitalized in the intensive care unit between 48 and 96 hours. One patient with a ferritin concentration < 100 mg/L was excluded to eliminate a possible coexistence of iron deficiency with inflammation. A statistically signifi- cant correlation was observed between C-reactive protein concentrations and CHr values (r =- 0.588; P = 0.03, n = 13). The results observed in this preliminary study are interesting and could be useful to establish the research protocol for a future study evaluating iron metabolism in criti- cally ill patients. A larger study is feasible and warranted given the results observed in this preliminary study.