{"title":"Obstructive nephropathy: What the surgical pathologist should know","authors":"L. Truong, K. Mai","doi":"10.1097/PCR.0000000000000118","DOIUrl":null,"url":null,"abstract":"Obstructive nephropathy (ON) represents renal changes due to urine obstruction, regardless of cause, anywhere between the ureteropelvic junction and the urethra. Obstructive nephropathy is the most frequent diagnosis in nephrectomy specimens for nonneoplastic conditions. Nephrectomy is usually indicated for advanced disease, causing irreversible loss of renal function or other complications such as intractable pain, recalcitrant hypertension, repeated infection, or bleeding. Grossly, ON is characterized by cortical thinning and dilatation of the pyelocaliceal system. Microscopically, ON represents a type of primary tubulointerstitial nephritis in which there is marked chronic tubulointerstitial injury, with disproportionately mild glomerular and vascular changes. The morphologic changes of ON are complex but characteristic, thus amenable to an accurate diagnosis. Obstructive nephropathy, however, may be complicated by other morphologically distinctive and clinically significant conditions, which should also receive diagnostic attention. These conditions include acute pyelonephritis, chronic pyelonephritis, granulomatous pyelitis, papillary necrosis, xanthogranulomatous pyelonephritis, malakoplakia, urine polyp, and renal hematoma.","PeriodicalId":43475,"journal":{"name":"AJSP-Reviews and Reports","volume":null,"pages":null},"PeriodicalIF":0.2000,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/PCR.0000000000000118","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"AJSP-Reviews and Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/PCR.0000000000000118","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
Abstract
Obstructive nephropathy (ON) represents renal changes due to urine obstruction, regardless of cause, anywhere between the ureteropelvic junction and the urethra. Obstructive nephropathy is the most frequent diagnosis in nephrectomy specimens for nonneoplastic conditions. Nephrectomy is usually indicated for advanced disease, causing irreversible loss of renal function or other complications such as intractable pain, recalcitrant hypertension, repeated infection, or bleeding. Grossly, ON is characterized by cortical thinning and dilatation of the pyelocaliceal system. Microscopically, ON represents a type of primary tubulointerstitial nephritis in which there is marked chronic tubulointerstitial injury, with disproportionately mild glomerular and vascular changes. The morphologic changes of ON are complex but characteristic, thus amenable to an accurate diagnosis. Obstructive nephropathy, however, may be complicated by other morphologically distinctive and clinically significant conditions, which should also receive diagnostic attention. These conditions include acute pyelonephritis, chronic pyelonephritis, granulomatous pyelitis, papillary necrosis, xanthogranulomatous pyelonephritis, malakoplakia, urine polyp, and renal hematoma.
期刊介绍:
Each issue of Pathology Case Reviews examines one vital theme in the field with peer-reviewed, clinically oriented case reports that focus on diagnosis, specimen handling and reports generation. Each theme-oriented issue covers both histopathologic and cytopathologic cases, offering a comprehensive perspective that includes editorials and review articles of the newest developments in the field, differential diagnosis hints, applications of new technologies, reviews of current issues and techniques and an emphasis on new approaches.