Inflammatory marker trajectories associated with frailty and ageing in a 20-year longitudinal study

IF 4.6 2区医学 Q2 IMMUNOLOGY

Clinical & Translational Immunology Pub Date : 2022-02-09 DOI:10.1002/cti2.1374

Leonard Dani?l Samson, Anne-Marie Buisman, José A Ferreira, H Susan J Picavet, W M Monique Verschuren, Annemieke MH Boots, Peter Engelfriet

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引用次数: 7

Abstract

Objective

The aim of this exploratory study was to investigate the development of low-grade inflammation during ageing and its relationship with frailty.

Methods

The trajectories of 18 inflammatory markers measured in blood samples, collected at 5-year intervals over a period of 20 years from 144 individuals aged 65–75 years at the study endpoint, were related to the degree of frailty later in life.

Results

IFN-γ-related markers and platelet activation markers were found to change in synchrony. Chronically elevated levels of IL-6 pathway markers, such as CRP and sIL-6R, were associated with more frailty, poorer lung function and reduced physical strength. Being overweight was a possible driver of these associations. More and stronger associations were detected in women, such as a relation between increasing sCD14 levels and frailty, indicating a possible role for monocyte overactivation. Multivariate prediction of frailty confirmed the main results, but predictive accuracy was low.

Conclusion

In summary, we documented temporal changes in and between inflammatory markers in an ageing population over a period of 20 years, and related these to clinically relevant health outcomes.

查看原文本刊更多论文

在一项20年的纵向研究中，与虚弱和衰老相关的炎症标志物轨迹

目的探讨低度炎症在衰老过程中的发展及其与机体虚弱的关系。方法:在研究结束时，144名65-75岁的人在20年的时间里每隔5年收集一次血液样本，在血液样本中测量18种炎症标志物的轨迹与晚年的虚弱程度有关。结果IFN-γ相关标志物和血小板活化标志物同步改变。长期升高的IL-6通路标志物，如CRP和sIL-6R，与更脆弱、肺功能更差和体力下降有关。超重可能是这些关联的驱动因素。在女性中检测到更多和更强的关联，例如sCD14水平升高与虚弱之间的关系，表明单核细胞过度激活可能起作用。虚弱的多因素预测证实了主要结果，但预测准确性较低。总之，我们记录了20年来老龄化人群中炎症标志物的时间变化及其之间的变化，并将其与临床相关的健康结果联系起来。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical & Translational Immunology Medicine-Immunology and Allergy

CiteScore

12.00

自引率

1.70%

发文量

审稿时长

13 weeks

期刊介绍： Clinical & Translational Immunology is an open access, fully peer-reviewed journal devoted to publishing cutting-edge advances in biomedical research for scientists and physicians. The Journal covers fields including cancer biology, cardiovascular research, gene therapy, immunology, vaccine development and disease pathogenesis and therapy at the earliest phases of investigation.