Congenital anomalies.

Abstract

only three reports in the literature in which tetanus antitoxin resulted in serum sickness and myocardial infarction. The authors report the case of a 32 year ol0( man in whom no evidence of arte-riosclerotic, hypertensive or syphilitic heart disease was present. Serum sickness followed the administration of 1500 units of tetanus antitoxin. Accompanying this serum sensitization the patient presented symptomatic as well as electrocardiographic evidence of a posterior myocardial infa1rc-tion. The infarction eventually healed and the patient recovered. The authors postulate that the serum sickness resulted in coronary arteritis comparable to that produced in animals by the injection of horse serum. This deals plrincipally with lhemoldynamic responses after the of The authors also studied the effects of I)HO on renal blood flow, cardiac output, and the resl)onse to atropine and epineplhrine. This synthetic atlkaloid inhibited or abolished the vaso-pressor rslponses to the Valsalva maneuver, upright tilting, and the cold pressor test. Skin temperature in the increased in al warm environment but not in a cool environment. Changes in bloo(l the extremities and the hepatoportal circu- lation were not constant after the intravenous injection of DHO. Clinically, the studies suggested that the agents have certain limitations in the treatment of essential alteration of the arterial circulation except for diminished oscillometric pulsations which subsequently improved with paravertebral novocaine block and then ganglionectomy. SCHWEDEL