A technique for accurate use of CD4+ cell counts.

K. Vedhara, K. Nott, S. M. Richards, C. Bradbeer, E. Davidson, E. Ong, Marcus H Snow
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引用次数: 0

Abstract

Despite uncertainty over their reliability, CD4+ cell counts are used extensively in both clinical and research settings to document progression in HIV infection. We examined, therefore, whether the performance of a simple statistical test would facilitate greater accuracy in the use of this marker. CD4+ cell count data were collected from a cohort of deceased (N = 60) and living HIV-positive gay men (N = 100). Pearson's product moment correlation coefficients were calculated for each individual in order to examine the association between CD4+ counts and time since diagnosis. Correlations of 0.7 or greater were obtained in approximately 50 percent of cases in each cohort. For these individuals, CD4+ cell counts were deemed to be a reliable indicator of rate of progression. The results suggest that the proposed technique ensures greater precision in the use of CD4+ cell counts and that the technique cna be used in individuals with either complete (deceased patients) or partial (living patients) CD4+ data.
一种精确使用CD4+细胞计数的技术。
尽管其可靠性存在不确定性,但CD4+细胞计数在临床和研究环境中广泛用于记录HIV感染的进展。因此,我们研究了简单统计检验的性能是否有助于提高使用该标记的准确性。CD4+细胞计数数据收集自一组死者(N = 60)和活着的hiv阳性男同性恋者(N = 100)。计算每个个体的Pearson积矩相关系数,以检查CD4+计数与诊断后时间之间的关系。在每个队列中,大约50%的病例获得0.7或更高的相关性。对于这些个体,CD4+细胞计数被认为是进展速度的可靠指标。结果表明,所提出的技术确保了CD4+细胞计数使用的更高精度,并且该技术可以用于具有完整(已故患者)或部分(活着的患者)CD4+数据的个体。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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