Renjith Rajan, S. Varghese, Rajani Kurup, R. Gopalakrishnan, R. Venkataraman, Krishnan Satheeshkumar, Sabulal Baby
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引用次数: 14
Abstract
Abstract Camptothecin (CPT), a modified monoterpene indole alkaloid, is a potential anticancer drug, and due to high demand, search for its new plant-based sources is a priority. Genus Ophiorrhiza is a candidate group in the search for new resources of CPT. Here, CPT contents in 38 Ophiorrhiza accessions, belonging to 11 species and 3 varieties, collected from the southern Western Ghats region in India were quantified by HPTLC-densitometry. Ophiorrhiza mungos (396.54 μg/g, dr. wt.) and O. mungos var. angustifolia (373.19 μg/g, dr. wt.) were the two best CPT sources among the screened species/varieties. O. rugosa var. decumbens (18.55 μg/g, dr. wt.) and O. hirsutula (17.14 μg/g, dr. wt.) showed moderate contents of CPT. This is the first systematic CPT screening of O. hirsutula, O. barnesii, O. incarnata, O. radicans and O. villosa. This study shows the significance of choosing high CPT-yielding ecotypes/chemotypes of Ophiorrhiza species or varieties for commercial purposes.
喜树碱(CPT)是一种改性的单萜吲哚生物碱，是一种潜在的抗癌药物，由于需求量大，寻找其新的植物来源是一个优先考虑的问题。蛇根属是寻找CPT新资源的候选类群。本文采用hptlc -密度法测定了采自印度西高止山脉南部地区的3个变种、11个种、38份蛇根的CPT含量。在筛选的种/品种中，芒戈(Ophiorrhiza mungos, 396.54 μg/g, dr. wt.)和芒戈(o.s mungos var. angustifolia, 373.19 μg/g, dr. wt.)是两个最佳的CPT源。褐花花(18.55 μg/g, dr. wt.)和毛花花(17.14 μg/g, dr. wt.)的CPT含量适中。这是第一次系统地对O. hirsutula、O. barnesii、O. incarnata、O. radicans和O. villosa进行CPT筛查。本研究表明，选择高cpt产量的麦根物种或品种的生态型/化学型具有商业意义。
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