Antiproliferative activities of several plant extracts from Turkey on rat brain tumor and human cervix carcinoma cell lines

Q1 Biochemistry, Genetics and Molecular Biology

Frontiers in Life Science Pub Date : 2016-01-02 DOI:10.1080/21553769.2015.1089949

A. ŞAHİN YAĞLIOĞLU, Ferda Eser, Ş. Tekin, A. Onal

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引用次数: 11

Abstract

Turkey has a wide range of flora and fauna due to its climatic diversity. Medicinal plants from Turkey have been used since ancient times for their primary health care. In this study, we examined antiproliferative activities of the extracts from Crataegus monogyna, Vitis vinifera, Glycrrhiza glabra, Alnus glutinosa L. gaertn, and Alcea rosea against rat brain tumor (C6) and human cervical cancer (HeLa) cell lines. The results were compared with the standard anticancer drugs 5-Flurouracil (5-FU) and Cisplatin. C. monogyna, V. vinifera and A. rosea exhibited better antiproliferative activity than 5-FU and cisplatin at 100-75 µg/mL concentrations, against C6 cell lines. On the other hand, C. monogyna and V. vinifera extracts showed considerable antiproliferative activity against HeLa cells compared with 5-FU and cisplatin at 100-75 µg/mL. It can be suggested that, C. monogyna, A. glutinosa L. gaertn, V. vinifera and A. rosea extracts could be developed as an anticancer drug. GRAPHICAL ABSTRACT

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土耳其几种植物提取物对大鼠脑肿瘤和人宫颈癌细胞系的抗增殖作用

由于气候的多样性，土耳其的动植物种类繁多。土耳其的药用植物自古以来就被用于初级保健。本实验研究了山楂、葡萄、光甘草、桤木和玫瑰alus提取物对大鼠脑瘤(C6)和人宫颈癌(HeLa)细胞系的增殖作用。结果与标准抗癌药物5-氟尿嘧啶(5-FU)和顺铂进行比较。在100 ~ 75µg/mL浓度下，单胞草、葡萄花和玫瑰花对C6细胞株的抑制作用优于5-FU和顺铂。另一方面，在100 ~ 75µg/mL浓度下，与5-FU和顺铂相比，红草和葡萄叶提取物对HeLa细胞具有明显的抗增殖活性。结果表明，金盏花、金盏花、葡萄花和玫瑰花提取物具有开发抗癌药物的潜力。图形抽象

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来源期刊

Frontiers in Life Science MULTIDISCIPLINARY SCIENCES-

CiteScore

5.50

自引率

0.00%

发文量

期刊介绍： Frontiers in Life Science publishes high quality and innovative research at the frontier of biology with an emphasis on interdisciplinary research. We particularly encourage manuscripts that lie at the interface of the life sciences and either the more quantitative sciences (including chemistry, physics, mathematics, and informatics) or the social sciences (philosophy, anthropology, sociology and epistemology). We believe that these various disciplines can all contribute to biological research and provide original insights to the most recurrent questions.