In-vivo and in-vitro techniques used to investigate Alzheimer's disease

Q1 Biochemistry, Genetics and Molecular Biology

Frontiers in Life Science Pub Date : 2015-06-02 DOI:10.1080/21553769.2015.1044129

Vishvanath Tiwari, Vandana Solanki, Monalisa Tiwari

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引用次数: 7

Abstract

Alzheimer's disease (AD) is one of the most common neurological diseases. It is characterized by the presence of β-amyloid peptides and highly phosphorylated tau proteins in the brain. The study of AD became more reliable with the development of new advances in both in-vivo (e.g. positron emission tomography, single-photon emission computed tomography, magnetic resonance imaging, functional magnetic resonance imaging, diffusion-weighted magnetic resonance imaging, and diffusion and perfusion magnetic resonance imaging) and in-vitro (e.g. circular dichroism, Fourier transform infrared spectroscopy, dye binding, transmission electron microscopy, scanning transmission electron microscopy, scanning tunnelling microscopy, atomic force microscopy and fluorescence resonance energy transfer) methods. These methods are used in the study of the pathogenesis and diagnosis of AD. Each method has its own advantages and limitations. This review explains the significance of different methods in understanding the pathogenesis of AD.

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用于研究阿尔茨海默病的体内和体外技术

阿尔茨海默病(AD)是最常见的神经系统疾病之一。它的特点是在大脑中存在β-淀粉样肽和高度磷酸化的tau蛋白。随着体内(如正电子发射断层扫描、单光子发射计算机断层扫描、磁共振成像、功能磁共振成像、扩散加权磁共振成像、扩散和灌注磁共振成像)和体外(如圆二色、傅里叶变换红外光谱、染料结合、透射电镜、扫描透射电子显微镜，扫描隧道显微镜，原子力显微镜和荧光共振能量转移)方法。这些方法用于阿尔茨海默病的发病机制和诊断的研究。每种方法都有自己的优点和局限性。本文就不同方法在了解AD发病机制中的意义作一综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Life Science MULTIDISCIPLINARY SCIENCES-

CiteScore

5.50

自引率

0.00%

发文量

期刊介绍： Frontiers in Life Science publishes high quality and innovative research at the frontier of biology with an emphasis on interdisciplinary research. We particularly encourage manuscripts that lie at the interface of the life sciences and either the more quantitative sciences (including chemistry, physics, mathematics, and informatics) or the social sciences (philosophy, anthropology, sociology and epistemology). We believe that these various disciplines can all contribute to biological research and provide original insights to the most recurrent questions.