Epimerization-Free C-Term Activation of Peptide Fragments by Ball Milling

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2021-01-04 DOI:10.1021/acs.orglett.0c03209

Yves Yeboue, Marion Jean, Gilles Subra, Jean Martinez, Frédéric Lamaty*, Thomas-Xavier Métro*

引用次数: 0

Abstract

Peptides were produced in high yields and, if any, very low epimerization, by mechanochemical coupling of peptide fragments containing highly epimerization-prone and/or highly hindered amino acids at C-term. Ball milling was clearly identified as the key element enabling one to obtain such results.

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球磨法制备无外聚体c -项激活肽片段

多肽的产率很高，如果有的话，是非常低的外显异构化，通过在C-term含有高度外显异构化倾向和/或高度受阻氨基酸的肽片段的机械化学偶联产生的。球磨被清楚地确定为能够获得这样的结果的关键因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.