Electrospun herbal nanofibrous wound dressings for skin tissue engineering

Abstract

Synthetic polymeric membranes are used for biomedical applications due to their remarkable structural, mechanical, and biocompatible behavior. Polycaprolactone (PCL) is a biopolymer widely used for tissue engineering applications, but the major limitation of PCL polymer is that it is hydrophobic in nature. The major focus of the work is to study the degradation and wettability behavior of aloe vera (AV)-incorporated elctrospun matrices. The AV-incorporated matrices degraded at a faster rate compared to PCL matrices. The hydrophilicity of the mat increased on blending the polymer with AV. Fibroblasts cells cultured on the PCL-AV showed rapid proliferation compared to that of pristine PCL mat.