Synthesis of (−)-menthol: Industrial synthesis routes and recent development

IF 2.1 3区 农林科学 Q3 CHEMISTRY, APPLIED
Dominik Dylong, Peter J. C. Hausoul, Regina Palkovits, Matthias Eisenacher
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引用次数: 0

Abstract

(−)-Menthol is one of the most popular aroma compounds worldwide. While in the past mostly extracted from mint plants, today (−)-menthol synthesis from other raw materials is becoming more relevant. Common starting materials for menthol synthesis are m-cresol, citral and myrcene, but also substrates like menthone, mono- and bicyclic terpenes and terpenoids have been used for this purpose in the past. As for many applications (−)-menthol of high purity is required, asymmetric syntheses and enantiomeric resolution of obtained raw products are applied for menthol production. This review gives an overview on the most important synthetic menthol production processes of the companies Symrise, Takasago and BASF and relevant literature in the field of menthol synthesis with a focus on the last 20 years.

Abstract Image

(−)-薄荷醇的合成:工业合成路线及最新进展
(−)-薄荷醇是世界上最受欢迎的芳香化合物之一。虽然过去主要是从薄荷植物中提取,但今天从其他原料合成(−)薄荷醇越来越重要。薄荷醇合成的常用起始原料是间甲酚、柠檬醛和月桂烯,但也有底物如薄荷酮、单环和双环萜烯和萜类在过去被用于此目的。对于许多需要高纯度(−)-薄荷醇的应用,采用不对称合成和对映体拆分得到的原料产品用于薄荷醇的生产。本文综述了Symrise、Takasago和BASF公司最重要的合成薄荷醇生产工艺,并重点介绍了近20年来在薄荷醇合成领域的相关文献。
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来源期刊
Flavour and Fragrance Journal
Flavour and Fragrance Journal 工程技术-食品科技
CiteScore
6.00
自引率
3.80%
发文量
40
审稿时长
1 months
期刊介绍: Flavour and Fragrance Journal publishes original research articles, reviews and special reports on all aspects of flavour and fragrance. Its high scientific standards and international character is ensured by a strict refereeing system and an editorial team representing the multidisciplinary expertise of our field of research. Because analysis is the matter of many submissions and supports the data used in many other domains, a special attention is placed on the quality of analytical techniques. All natural or synthetic products eliciting or influencing a sensory stimulus related to gustation or olfaction are eligible for publication in the Journal. Eligible as well are the techniques related to their preparation, characterization and safety. This notably involves analytical and sensory analysis, physical chemistry, modeling, microbiology – antimicrobial properties, biology, chemosensory perception and legislation. The overall aim is to produce a journal of the highest quality which provides a scientific forum for academia as well as for industry on all aspects of flavors, fragrances and related materials, and which is valued by readers and contributors alike.
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