Review Questions

Abstract

5. Is the apolipoprotein e genotype a risk factor for type III hyperlipoproteinemia? A. Yes, genotype e2e2 is obligate. B. No, type III hyperlipoproteinemia is defined as a disease with increased remnants (b-VLDL) concentration, this is only a qualitative criterion. A quantitative criterion as the ratio VLDL-chol/plasma TG> 0.69 was found to be diagnostic for type III. C. Next to e2e2, increased remnants (VLDLchol/plasma TG) can also occur in variants of apo E as well as in heterozygotes for apo E2; for example: genotype e3e2 or e4e2. D. The phenotype is much more relevant then the genotype because of the interaction with additional metabolic factors.