Drugs targeting insulin-like growth factor 1 receptor

T. Mayer, L. Harris, M. DiGiovanna
{"title":"Drugs targeting insulin-like growth factor 1 receptor","authors":"T. Mayer, L. Harris, M. DiGiovanna","doi":"10.1017/S1470903109990058","DOIUrl":null,"url":null,"abstract":"14622. 59. Wittman M, Carboni J, Attar R, et al. Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitumor activity. J Med Chem 2005; 48(18): 5639–5643. 60. Mulvihill M, Qun-Sheng J, Rosenfeld-Franklin M, et al. The discovery of OSI-906: a novel, potent, orally bioavailable imidazopyrazine-derived insulin-like growth factor-I receptor (IGF-1R) inhibitor with antitumor activity. AACR Annual Meeting 2008: abstract 4893. 61. Burtrum D, Zhu Z, Lu D, et al. A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo. Cancer Res 2003; 63(24): 8912–8921. 62. Cohen B, Baker D, Soderstrom C, et al. Combination therapy enhances the inhibition of tumor growth with the fully human anti-type 1 insulin-like growth factor receptor monoclonal antibody CP-751,871. Clin Cancer Res 2005; 11(5): 2063–2073. 63. Goetsch L, Gonzalez A, Leger O, et al. A recombinant humanized anti-insulin-like growth factor receptor type I antibody (h7C10) enhances the antitumor activity of vinorelbine and anti-epidermal growth factor receptor therapy against human cancer xenografts. Int J Cancer 2005; 113(2): 316–328. 64. Maloney E, McLaughlin J, Dagdigian N, et al. An antiinsulin-like growth factor I receptor antibody that is a potent inhibitor of cancer cell proliferation. Cancer Res 2003; 63(16): 5073–5083. 65. Sachdev D, Li S, Hartell J, Fujita-Yamaguchi Y, Miller J, Yee D. A chimeric humanized single-chain antibody against the type I insulin-like growth factor (IGF) receptor renders breast cancer cells refractory to the mitogenic effects of IGF-I. Cancer Res 2003; 63(3): 627–635. 66. Wang Y, Hailey J, Williams D, et al. Inhibition of insulinlike growth factor-I receptor (IGF-IR) signaling and tumor cell growth by a fully human neutralizing anti-IGF-IR antibody. Mol Cancer Ther 2005; 4(8): 1214–1221. 67. Haluska P, Shaw H, Batzel G, et al. Phase I dose escalation study of the anti insulin-like growth factor-I receptor monoclonal antibody CP-751,871 in patients with refractory solid tumors. Clin Cancer Res 2007; 13(19): 5834–5840. Drugs targeting insulin-like growth factor 1 receptor Page 9 of 10 https://www.cambridge.org/core/terms. https://doi.org/10.1017/S1470903109990058 Downloaded from https://www.cambridge.org/core. IP address: 207.241.231.82, on 24 Jul 2018 at 13:47:50, subject to the Cambridge Core terms of use, available at 68. Lacy M, Alsina M, Fonseca R, et al. Phase I, Pharmacokinetic and Pharmacodynamic Study of the AntiInsulin like Growth Factor Type 1 Receptor Monoclonal Antibody CP-751,871 in Patients With Multiple Myeloma. J Clin Oncol 2008; 26(19): 3196–3203. 69. Karp D, Paz-Ares L, Novello P, et al. High activity of the anti-IGF-IR antibody CP-751,871 in combination with paclitaxel and carboplatin in squamous NSCLC. J Clin Oncol 2008; 26: abstract 8015. 70. Hidalgo M, Tirado Gomez M, Lewis N, et al. A phase I study of MK-0646, a humanized monoclonal antibody against the insulin-like growth factor receptor type 1 (IGF-IR) in advanced solid tumor patients in a q2 wk schedule. J Clin Oncol 2008; 26: abstract 3520. 71. Atzori F, Tabernero A, Cervantes A, et al. A phase I, pharmacokinetic (PK) and pharmacodynamic (PD) study of weekly (qW) MK-0646, an insulin-like growth factor-1 receptor (IGF-IR) monoclonal antibody (MAb) in patients (pts) with advanced solid tumors. J Clin Oncol 2008; 26: abstract 3519. 72. Beltran P, Mitchell P, Moody G, et al. AMG-479, a fully human anti IGF-1 receptor antibody, inhibits PI3K/Akt3519. 72. Beltran P, Mitchell P, Moody G, et al. AMG-479, a fully human anti IGF-1 receptor antibody, inhibits PI3K/Akt signaling and exerts potent antitumor effects in combination with EGF-R inhibitors in pancreatic xenograft models. Gastrointestinal Cancers Symposium, American Society of Clinical Oncology, Orlando, FL, USA, 2007: abstract 208. 73. Sarantpoulos J, Mita A, Mulay M, et al. A phase IB study of AMG 479, a type 1 insulin-like growth factor receptor (IGF-1R) antibody, in combination with panitumumab (P) or gemcitabine (G). J Clin Oncol 2008; 26: abstract 3583. 74. Tolcher A, Rothenberg M, Rodon J, et al. A phase I pharmacokinetic and pharmacodynamic study of AMG 479, a fully human monoclonal antibody against insulinlike growth factor type 1 receptor (IGF-1R), in advanced solid tumors. J Clin Oncol 2007; 25: abstract 3002. 75. Rodon J, Patnaik A, Stein M, et al. A phase I study of q3W R1507, a human monoclonal antibody IGF-1R antagonist in patients with advanced cancer. J Clin Oncol 2007; 25: abstract 3590. 76. Rowinsky E, Youssoufian H, Tonra J, Solomon P, Burtrum D, Ludwig D. IMC-A12, a human IgG1 monoclonal antibody to the insulin-like growth factor I receptor. Clin Cancer Res 2007; 13: 5549s–5555s. 77. Higano C, Yu E, Whiting S, et al. A phase I, first in man study of weekly IMC-A12, a fully human insulin like growth factor-I receptor IgG1 monoclonal antibody, in patients with advanced solid tumors. Prostate Cancer Symposium, American Society of Clinical Oncology, Orlando, FL, USA, 2007: abstract 269. 78. Tolcher A, Patnaik A, Till E, et al. A phase I study of AVE1642, a humanized monoclonal antibody IGF-1R (insulin like growth factor 1 receptor) antagonist, in patients (pts) with advanced solid tumors (ST). J Clin Oncol 2008; 26: abstract 3582. 79. Dong J, Tamraz S, Berquist L, et al. BIIB022, a human antibody targeting human insulin-like growth factor-1 receptor (IGF-1R), enhances the anti-tumor activities of Tarceva in non-small cell lung carcinoma (NSCLC) and rapamycin in sarcoma cell lines. AACR Annual Meeting 2008: abstract 4002. 80. Girnita A, Girnita L, del Prete F, Bartolazzi A, Larsson O, Axelson M. Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth. Cancer Res 2004; 64(1): 236–242. 81. Gable K, Maddux B, Penaranda C, et al. Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth. Mol Cancer Ther 2006; 5(4): 1079–1086. 82. D’cunja J, Shalaby T, Rivera P, et al. Antisense treatment of IGF-IR induces apoptosis and enhances chemosensitivity in central nervous system atypical teratoid/ rhabdoid tumours cells. Eur J Cancer 2007; 43(10): 1581–1589. 83. Neuenschwander S, Roberts CJ, LeRoith D. Growth inhibition of MCF-7 breast cancer cells by stable expression of an insulin-like growth factor I receptor antisense ribonucleic acid. Endocrinology 1995; 136(10): 4298–4303. 84. Moses A, Young S, Morrow L, O’Brien M, Clemmons D. Recombinant human insulin-like growth factor I increases insulin sensitivity and improves glycemic control in type II diabetes. Diabetes 1996; 45(1): 91–100. 85. Schmitz F, Hartmann H, Stümpel F, Creutzfeldt W. In vivo metabolic action of insulin-like growth factor I in adult rats. Diabetologia 1991; 34(3): 144–149. 86. Soos M, Whittaker J, Lammers R, Ullrich A, Siddle K. Receptors for insulin and insulin-like growth factor-I can form hybrid dimers. Characterisation of hybrid receptors in transfected cells. Biochem J 1990; 270(2): 383–390. 87. Ullrich A, Gray A, Tam A, et al. Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity. EMBO J 1986; 5(10): 2503–2512. 88. Yee D. Targeting insulin-like growth factor pathways. Br J Cancer 2006; 94(4): 465–468. 89. Sachdev D, Yee D. Inhibitors of insulin-like growth factor signaling: a therapeutic approach for breast cancer. J Mammary Gland Biol Neoplasia 2006; 11(1): 27–39. 90. Miyagawa S, Kobayashi M, Konishi N, Sato T, Ueda K. Insulin and insulin-like growth factor I support the proliferation of erythroid progenitor cells in bone marrow through the sharing of receptors. Br J Haematol 2000; 109(3): 555–562. 91. Masuda S, Chikuma M, Sasaki R. Insulin-like growth factors and insulin stimulate erythropoietin production in primary cultured astrocytes. Brain Res 1997; 746(1–2): 63–70. 92. Okajima Y, Matsumura I, Nishiura T, et al. Insulin-like growth factor-I augments erythropoietin-induced proliferation through enhanced tyrosine phosphorylation of STAT5. J Biol Chem 1998; 273: 22877–22883. 93. Huang F, Hurlburt W, Hafezi R, et al. Identification of sensitivity markers for BMS-536924, an inhibitor for insulin-like growth factor-1 receptor. J Clin Oncol 2007; 25: abstract 3506. 94. Warshamana-Greene G, Litz J, Buchdunger E, Garcı́aEcheverrı́a C, Hofmann F, Krystal G. The insulin-like growth factor-I receptor kinase inhibitor, NVP-ADW742, sensitizes small cell lung cancer cell lines to the effects of chemotherapy. Clin Cancer Res 2005; 11(4): 1563–1571. Page 10 of 10 T. Mayer et al. https://www.cambridge.org/core/terms. https://doi.org/10.1017/S1470903109990058 Downloaded from https://www.cambridge.org/core. 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引用次数: 1

Abstract

14622. 59. Wittman M, Carboni J, Attar R, et al. Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitumor activity. J Med Chem 2005; 48(18): 5639–5643. 60. Mulvihill M, Qun-Sheng J, Rosenfeld-Franklin M, et al. The discovery of OSI-906: a novel, potent, orally bioavailable imidazopyrazine-derived insulin-like growth factor-I receptor (IGF-1R) inhibitor with antitumor activity. AACR Annual Meeting 2008: abstract 4893. 61. Burtrum D, Zhu Z, Lu D, et al. A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo. Cancer Res 2003; 63(24): 8912–8921. 62. Cohen B, Baker D, Soderstrom C, et al. Combination therapy enhances the inhibition of tumor growth with the fully human anti-type 1 insulin-like growth factor receptor monoclonal antibody CP-751,871. Clin Cancer Res 2005; 11(5): 2063–2073. 63. Goetsch L, Gonzalez A, Leger O, et al. A recombinant humanized anti-insulin-like growth factor receptor type I antibody (h7C10) enhances the antitumor activity of vinorelbine and anti-epidermal growth factor receptor therapy against human cancer xenografts. Int J Cancer 2005; 113(2): 316–328. 64. Maloney E, McLaughlin J, Dagdigian N, et al. An antiinsulin-like growth factor I receptor antibody that is a potent inhibitor of cancer cell proliferation. Cancer Res 2003; 63(16): 5073–5083. 65. Sachdev D, Li S, Hartell J, Fujita-Yamaguchi Y, Miller J, Yee D. A chimeric humanized single-chain antibody against the type I insulin-like growth factor (IGF) receptor renders breast cancer cells refractory to the mitogenic effects of IGF-I. Cancer Res 2003; 63(3): 627–635. 66. Wang Y, Hailey J, Williams D, et al. Inhibition of insulinlike growth factor-I receptor (IGF-IR) signaling and tumor cell growth by a fully human neutralizing anti-IGF-IR antibody. Mol Cancer Ther 2005; 4(8): 1214–1221. 67. Haluska P, Shaw H, Batzel G, et al. Phase I dose escalation study of the anti insulin-like growth factor-I receptor monoclonal antibody CP-751,871 in patients with refractory solid tumors. Clin Cancer Res 2007; 13(19): 5834–5840. Drugs targeting insulin-like growth factor 1 receptor Page 9 of 10 https://www.cambridge.org/core/terms. https://doi.org/10.1017/S1470903109990058 Downloaded from https://www.cambridge.org/core. IP address: 207.241.231.82, on 24 Jul 2018 at 13:47:50, subject to the Cambridge Core terms of use, available at 68. Lacy M, Alsina M, Fonseca R, et al. Phase I, Pharmacokinetic and Pharmacodynamic Study of the AntiInsulin like Growth Factor Type 1 Receptor Monoclonal Antibody CP-751,871 in Patients With Multiple Myeloma. J Clin Oncol 2008; 26(19): 3196–3203. 69. Karp D, Paz-Ares L, Novello P, et al. High activity of the anti-IGF-IR antibody CP-751,871 in combination with paclitaxel and carboplatin in squamous NSCLC. J Clin Oncol 2008; 26: abstract 8015. 70. Hidalgo M, Tirado Gomez M, Lewis N, et al. A phase I study of MK-0646, a humanized monoclonal antibody against the insulin-like growth factor receptor type 1 (IGF-IR) in advanced solid tumor patients in a q2 wk schedule. J Clin Oncol 2008; 26: abstract 3520. 71. Atzori F, Tabernero A, Cervantes A, et al. A phase I, pharmacokinetic (PK) and pharmacodynamic (PD) study of weekly (qW) MK-0646, an insulin-like growth factor-1 receptor (IGF-IR) monoclonal antibody (MAb) in patients (pts) with advanced solid tumors. J Clin Oncol 2008; 26: abstract 3519. 72. Beltran P, Mitchell P, Moody G, et al. AMG-479, a fully human anti IGF-1 receptor antibody, inhibits PI3K/Akt3519. 72. Beltran P, Mitchell P, Moody G, et al. AMG-479, a fully human anti IGF-1 receptor antibody, inhibits PI3K/Akt signaling and exerts potent antitumor effects in combination with EGF-R inhibitors in pancreatic xenograft models. Gastrointestinal Cancers Symposium, American Society of Clinical Oncology, Orlando, FL, USA, 2007: abstract 208. 73. Sarantpoulos J, Mita A, Mulay M, et al. A phase IB study of AMG 479, a type 1 insulin-like growth factor receptor (IGF-1R) antibody, in combination with panitumumab (P) or gemcitabine (G). J Clin Oncol 2008; 26: abstract 3583. 74. Tolcher A, Rothenberg M, Rodon J, et al. A phase I pharmacokinetic and pharmacodynamic study of AMG 479, a fully human monoclonal antibody against insulinlike growth factor type 1 receptor (IGF-1R), in advanced solid tumors. J Clin Oncol 2007; 25: abstract 3002. 75. Rodon J, Patnaik A, Stein M, et al. A phase I study of q3W R1507, a human monoclonal antibody IGF-1R antagonist in patients with advanced cancer. J Clin Oncol 2007; 25: abstract 3590. 76. Rowinsky E, Youssoufian H, Tonra J, Solomon P, Burtrum D, Ludwig D. IMC-A12, a human IgG1 monoclonal antibody to the insulin-like growth factor I receptor. Clin Cancer Res 2007; 13: 5549s–5555s. 77. Higano C, Yu E, Whiting S, et al. A phase I, first in man study of weekly IMC-A12, a fully human insulin like growth factor-I receptor IgG1 monoclonal antibody, in patients with advanced solid tumors. Prostate Cancer Symposium, American Society of Clinical Oncology, Orlando, FL, USA, 2007: abstract 269. 78. Tolcher A, Patnaik A, Till E, et al. A phase I study of AVE1642, a humanized monoclonal antibody IGF-1R (insulin like growth factor 1 receptor) antagonist, in patients (pts) with advanced solid tumors (ST). J Clin Oncol 2008; 26: abstract 3582. 79. Dong J, Tamraz S, Berquist L, et al. BIIB022, a human antibody targeting human insulin-like growth factor-1 receptor (IGF-1R), enhances the anti-tumor activities of Tarceva in non-small cell lung carcinoma (NSCLC) and rapamycin in sarcoma cell lines. AACR Annual Meeting 2008: abstract 4002. 80. Girnita A, Girnita L, del Prete F, Bartolazzi A, Larsson O, Axelson M. Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth. Cancer Res 2004; 64(1): 236–242. 81. Gable K, Maddux B, Penaranda C, et al. Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth. Mol Cancer Ther 2006; 5(4): 1079–1086. 82. D’cunja J, Shalaby T, Rivera P, et al. Antisense treatment of IGF-IR induces apoptosis and enhances chemosensitivity in central nervous system atypical teratoid/ rhabdoid tumours cells. Eur J Cancer 2007; 43(10): 1581–1589. 83. Neuenschwander S, Roberts CJ, LeRoith D. Growth inhibition of MCF-7 breast cancer cells by stable expression of an insulin-like growth factor I receptor antisense ribonucleic acid. Endocrinology 1995; 136(10): 4298–4303. 84. Moses A, Young S, Morrow L, O’Brien M, Clemmons D. Recombinant human insulin-like growth factor I increases insulin sensitivity and improves glycemic control in type II diabetes. Diabetes 1996; 45(1): 91–100. 85. Schmitz F, Hartmann H, Stümpel F, Creutzfeldt W. In vivo metabolic action of insulin-like growth factor I in adult rats. Diabetologia 1991; 34(3): 144–149. 86. Soos M, Whittaker J, Lammers R, Ullrich A, Siddle K. Receptors for insulin and insulin-like growth factor-I can form hybrid dimers. Characterisation of hybrid receptors in transfected cells. Biochem J 1990; 270(2): 383–390. 87. Ullrich A, Gray A, Tam A, et al. Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity. EMBO J 1986; 5(10): 2503–2512. 88. Yee D. Targeting insulin-like growth factor pathways. Br J Cancer 2006; 94(4): 465–468. 89. Sachdev D, Yee D. Inhibitors of insulin-like growth factor signaling: a therapeutic approach for breast cancer. J Mammary Gland Biol Neoplasia 2006; 11(1): 27–39. 90. Miyagawa S, Kobayashi M, Konishi N, Sato T, Ueda K. Insulin and insulin-like growth factor I support the proliferation of erythroid progenitor cells in bone marrow through the sharing of receptors. Br J Haematol 2000; 109(3): 555–562. 91. Masuda S, Chikuma M, Sasaki R. Insulin-like growth factors and insulin stimulate erythropoietin production in primary cultured astrocytes. Brain Res 1997; 746(1–2): 63–70. 92. Okajima Y, Matsumura I, Nishiura T, et al. Insulin-like growth factor-I augments erythropoietin-induced proliferation through enhanced tyrosine phosphorylation of STAT5. J Biol Chem 1998; 273: 22877–22883. 93. Huang F, Hurlburt W, Hafezi R, et al. Identification of sensitivity markers for BMS-536924, an inhibitor for insulin-like growth factor-1 receptor. J Clin Oncol 2007; 25: abstract 3506. 94. Warshamana-Greene G, Litz J, Buchdunger E, Garcı́aEcheverrı́a C, Hofmann F, Krystal G. The insulin-like growth factor-I receptor kinase inhibitor, NVP-ADW742, sensitizes small cell lung cancer cell lines to the effects of chemotherapy. Clin Cancer Res 2005; 11(4): 1563–1571. Page 10 of 10 T. Mayer et al. https://www.cambridge.org/core/terms. https://doi.org/10.1017/S1470903109990058 Downloaded from https://www.cambridge.org/core. IP address: 207.241.231.82, on 24 Jul 2018 at 13:47:50, subject to the Cambridge Core terms of use, available at
胰岛素样生长因子1受体靶向药物
14622. 59. 李建军,李建军,李建军,等。发现具有体内抗肿瘤活性的胰岛素样生长因子I受体激酶(1h -苯并咪唑-2-基)- 1h -吡啶-2- 1 (BMS-536924)抑制剂。中华医学杂志2005;48(18): 5639 - 5643。60. Mulvihill M, quun - sheng J, Rosenfeld-Franklin M,等。osi906的发现:一种新的,有效的,口服生物可利用的咪唑吡嗪衍生的胰岛素样生长因子-1受体(IGF-1R)抑制剂,具有抗肿瘤活性。AACR 2008年年会:摘要4893。61. 波特鲁姆,朱忠,吕东,等。胰岛素样生长因子I受体的全人单克隆抗体阻断配体依赖性信号传导并抑制体内人肿瘤生长。癌症研究2003;63(24): 8912 - 8921。62. 王晓东,王晓东,王晓东,等。联合使用全人源抗1型胰岛素样生长因子受体单克隆抗体cp - 751871增强肿瘤生长抑制作用。临床癌症研究2005;11(5): 2063 - 2073。63. 李建军,李建军,李建军,等。一种重组人源抗胰岛素样生长因子受体I型抗体(h7C10)增强了长春瑞滨和抗表皮生长因子受体治疗对人肿瘤异种移植物的抗肿瘤活性。国际癌症杂志2005;113(2): 316 - 328。64. 马洛尼E,麦克劳克林J, Dagdigian N,等。一种抗胰岛素样生长因子I受体抗体,是一种有效的癌细胞增殖抑制剂。癌症研究2003;63(16): 5073 - 5083。65. 李建军,李建军,李建军,李建军,李建军。胰岛素样生长因子(IGF)受体单链抗体对乳腺癌细胞有丝分裂的抑制作用。癌症研究2003;63(3): 627 - 635。66. 王勇,Hailey J, Williams D,等。胰岛素样生长因子- 1受体(IGF-IR)信号传导和肿瘤细胞生长的抑制作用癌症杂志2005;4(8): 1214 - 1221。67. 刘建军,刘建军,刘建军,等。抗胰岛素样生长因子- 1受体单克隆抗体cp - 751871在难治性实体瘤患者中的一期剂量递增研究临床癌症研究2007;13(19): 5834 - 5840。靶向胰岛素样生长因子1受体的药物https://www.cambridge.org/core/terms。https://doi.org/10.1017/S1470903109990058从https://www.cambridge.org/core下载。IP地址:207.241.231.82,于2018年7月24日13:47:50发布,受剑桥核心使用条款约束,价格为68。Lacy M, Alsina M, Fonseca R,等。抗胰岛素样生长因子1型受体单克隆抗体cp - 751871在多发性骨髓瘤患者中的I期药代动力学和药效学研究中华临床杂志2008;26日(19):3196 - 3203。69. 李建军,李建军,李建军,等。抗igf - ir抗体cp - 751871联合紫杉醇和卡铂治疗鳞状NSCLC的高活性研究中华临床杂志2008;[26]摘要8015。70. Hidalgo M, Tirado Gomez M, Lewis N,等。MK-0646是一种针对胰岛素样生长因子受体1型(IGF-IR)的人源化单克隆抗体,在晚期实体瘤患者中的I期研究将在2周内进行。中华临床杂志2008;26:摘要3520。71. 阿佐里F,塔伯内罗A,塞万提斯A,等。一项针对晚期实体瘤患者(pts)的胰岛素样生长因子-1受体(IGF-IR)单克隆抗体(MAb) MK-0646的I期药代动力学(PK)和药效学(PD)研究。中华临床杂志2008;26:摘要3519。72. 张建军,张建军,张建军,等。AMG-479是一种全人源抗IGF-1受体抗体,可抑制PI3K/Akt3519。72. 张建军,张建军,张建军,等。AMG-479是一种完全人抗IGF-1受体抗体,在胰腺异种移植模型中抑制PI3K/Akt信号,并与EGF-R抑制剂联合发挥有效的抗肿瘤作用。胃肠肿瘤研讨会,美国临床肿瘤学会,奥兰多,FL, USA, 2007:摘要208。73. 张建军,张建军,张建军,等。1型胰岛素样生长因子受体(IGF-1R)抗体AMG 479联合帕尼单抗(P)或吉西他滨(G)的IB期研究。26:摘要3583。74. 张建军,张建军,张建军,等。AMG 479是一种抗胰岛素样生长因子1型受体(IGF-1R)的全人源单克隆抗体,用于晚期实体瘤的I期药代动力学和药效学研究。中华临床杂志2007;[25]摘要3002。75. Rodon J, Patnaik A, Stein M,等。q3W R1507是一种人单克隆抗体IGF-1R拮抗剂,用于晚期癌症患者的I期研究。中华临床杂志2007;25:摘要3590。76. 罗温斯基,李建军,李建军,李建军,等。胰岛素样生长因子1受体IgG1单克隆抗体的克隆及表达。临床癌症研究2007;13: 5549年代- 5555年代。77. 刘建军,刘建军,李建军,等。 IMC-A12是一种完全人胰岛素样生长因子-I受体IgG1单克隆抗体,用于晚期实体瘤患者的每周一次的I期临床研究。前列腺癌研讨会,美国临床肿瘤学会,奥兰多,佛罗里达州,美国,2007:摘要269。78. 张建军,张建军,张建军,等。AVE1642是一种人源化单克隆抗体IGF-1R(胰岛素样生长因子1受体)拮抗剂,用于晚期实体瘤(ST)患者的I期研究。中华临床杂志2008;26:摘要3582。79. 董军,李建平,李建平,等。BIIB022是一种靶向人胰岛素样生长因子-1受体(IGF-1R)的人抗体,可增强特罗凯在非小细胞肺癌(NSCLC)中的抗肿瘤活性和雷帕霉素在肉瘤细胞系中的抗肿瘤活性。AACR 2008年年会:摘要4002。80. 陈建军,陈建军,陈建军,陈建军,陈建军,等。Cyclolignans对胰岛素样生长因子-1受体的抑制作用。癌症研究2004;64(1): 236 - 242。81. 李建军,李建军,李建军,等。二Diarylureas是胰岛素样生长因子I受体信号传导和乳腺癌细胞生长的小分子抑制剂。癌症学报;2006;5(4): 1079 - 1086。82. 李建军,李建军,李建军,等。IGF-IR反义处理可诱导中枢神经系统非典型畸胎瘤/横纹肌样肿瘤细胞凋亡并增强化疗敏感性。中华医学杂志2007;43(10): 1581 - 1589。83. 李建军,李建军,李建军,等。胰岛素样生长因子1受体反义核糖核酸稳定表达对MCF-7乳腺癌细胞生长的抑制作用。内分泌学1995;136(10): 4298 - 4303。84. 李建军,杨建军,李建军,等。重组人胰岛素样生长因子I对2型糖尿病胰岛素敏感性和血糖控制的影响。糖尿病1996;45(1): 91 - 100。85. 李建军,李建军,李建军,等。胰岛素样生长因子1在大鼠体内代谢中的作用。Diabetologia 1991;34(3): 144 - 149。86. 李建军,李建军,李建军,等。胰岛素样生长因子- 1受体的克隆与表达。转染细胞中杂交受体的特性。生物化学杂志1990;270(2): 383 - 390。87. 吴丽娟,葛蕾,谭,等。胰岛素样生长因子I受体初级结构:与胰岛素受体的比较表明结构决定因素决定了功能特异性。Embo j 1986;5(10): 2503 - 2512。88. 靶向胰岛素样生长因子通路。中华医学杂志2006;94(4): 465 - 468。89. 李建平,李建平。胰岛素样生长因子信号传导抑制剂在乳腺癌治疗中的应用。乳腺生物学杂志;2006;11(1): 27-39。90. Miyagawa M, Kobayashi M, Konishi N, Sato T, Ueda K.胰岛素和胰岛素样生长因子I通过共享受体支持骨髓红细胞祖细胞增殖。[J]中华医学杂志2000;109(3): 555 - 562。91. 马志强,陈志强,陈志强,等。胰岛素样生长因子对星形胶质细胞促红细胞生成素产生的影响。大脑研究1997;746(2): 63 - 70。92. 李建平,李建平,李建平,等。胰岛素样生长因子- 1通过增强酪氨酸磷酸化STAT5增强促红细胞生成素诱导的增殖。生物化学学报(英文版);273: 22877 - 22883。93. 黄峰,胡尔柏,胡菲子,等。胰岛素样生长因子-1受体抑制剂BMS-536924敏感性标志物的鉴定中华临床杂志2007;25:摘要3506。94. 张建军,李建军,李建军,等。胰岛素样生长因子- 1受体激酶抑制剂nfp - adw742对肺癌细胞化疗敏感性的影响。临床癌症研究2005;11(4): 1563 - 1571。T. Mayer等人https://www.cambridge.org/core/terms。https://doi.org/10.1017/S1470903109990058从https://www.cambridge.org/core下载。IP地址:207.241.231.82,2018年7月24日13:47:50,受剑桥核心使用条款的约束,可在
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