{"title":"The modulation of immunity by dendritic cells","authors":"Nina Bhardwaj M.D., Ph.D.","doi":"10.1016/S1529-1049(02)00159-9","DOIUrl":null,"url":null,"abstract":"<div><p>T cell immunity is initiated by specialized antigen presenting cells known as dendritic cells (DCs). Antigen-pulsed DCs have been used to induce anti-tumor T cell and clinical responses in humans, apparently without significant toxicity. Under certain conditions, DCs even silence T cell immune responses in vivo. Therefore, DCs may be valuable tools for modulating immunity in the setting of autoimmunity, cancer, and chronic viral infections.</p></div>","PeriodicalId":89340,"journal":{"name":"Clinical and applied immunology reviews","volume":"3 4","pages":"Pages 173-182"},"PeriodicalIF":0.0000,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1529-1049(02)00159-9","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and applied immunology reviews","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1529104902001599","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
Abstract
T cell immunity is initiated by specialized antigen presenting cells known as dendritic cells (DCs). Antigen-pulsed DCs have been used to induce anti-tumor T cell and clinical responses in humans, apparently without significant toxicity. Under certain conditions, DCs even silence T cell immune responses in vivo. Therefore, DCs may be valuable tools for modulating immunity in the setting of autoimmunity, cancer, and chronic viral infections.
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