Relación de la saturación de O2 en la prueba de los seis minutos marcha con la masa muscular y la fuerza de contracción del cuádriceps en hombres con EPOC

Q4 Medicine

Revista de Patologia Respiratoria Pub Date : 2011-07-01 DOI:10.1016/S1576-9895(11)70113-8

C. Gutiérrez Ortega , F.J. Gómez de Terreros Sánchez , F.J. Gómez de Terreros Caro , L. Callol Sánchez

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引用次数: 1

Abstract

Hypothesis

Among the causes of muscle dysfunction in COPD, mention has been made of decreased oxygen delivery during exercise. Saturation levels during the 6 minutes walking test could be associated to muscle mass and function.

Population, material and methods

A group of 75 males patients, 48 (68.6%) males with COPD in different GOLD stages and 28 (74%) with chronic bronchitis (CB) were studied. Tests performed were spirometry, body mass composition analysis, 6 minutes walking test (6MWT), recording of mean hemoglobin saturation and greater or less than 4%, quadriceps voluntary contraction strength test (QMVC). Work performed (Ww) was determined by the Chuang equation and muscle mass by the Janssen Equation.

Results

No statistical differences were found in age, body mass index (BMI), free fat mass index (FFMI), muscle mass index (MMI) and QMVC, 6MWT and Ww between the COPD and CB groups. Desaturation ≥ 4% was more frequent in the COPD group (p < 0.01) and was related with a limitation in the distance walked (p = 0.025). The mean SpO₂ after 6MWT of ≤ 89% differentiates the COPD from the CB population (p = 0.002). We found no relationship between the different levels of SpO₂ after the walk test and muscle mass parameters (MMI, FFMI).

There was a statistical difference between patients with a mean SpO₂ after the walk test ≤ 90% and the distance reached (p = 0.04). When the mean SpO₂ was ≤ 89%, there was a decrease in the WW (p = 0.032). When the mean SpO2 was ≤ 88% we found a decrease in the QMVC (p = 0.05).

Conclusions

After the 6MWT, SpO₂ is more frequent, this having no relationship with the GOLD stage and is only related with the distance reached. Mean SpO₂ after the 6MWT is more sensitive since it is related to performance parameters in the first place, then with muscle strength, and later with quadriceps contraction strength. We found no relationship between the desaturation parameters studied and the muscle mass measurements.

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慢性阻塞性肺病男性6分钟步行试验中氧饱和度与肌肉质量和股四头肌收缩力的关系

在COPD患者肌肉功能障碍的原因中，已经提到了运动时氧气输送减少。6分钟步行测试期间的饱和水平可能与肌肉质量和功能有关。人群、材料与方法研究75例男性COPD不同GOLD期患者48例(68.6%)，慢性支气管炎(CB)患者28例(74%)。试验包括肺活量测定、体质量组成分析、6分钟步行试验(6MWT)、平均血红蛋白饱和度及大于或小于4%的记录、股四头肌自主收缩强度试验(QMVC)。完成的功(Ww)由Chuang方程确定，肌肉质量由Janssen方程确定。结果COPD组与CB组在年龄、身体质量指数(BMI)、游离脂肪质量指数(FFMI)、肌肉质量指数(MMI)、QMVC、6MWT、Ww等指标上均无统计学差异。去饱和≥4%在COPD组更常见(p <0.01)，并与行走距离限制有关(p = 0.025)。6MWT后SpO2均值≤89%是COPD与CB人群的鉴别指标(p = 0.002)。我们发现步行试验后不同水平的SpO2与肌肉质量参数(MMI, FFMI)之间没有关系。步行测试后SpO2均值≤90%的患者与行走距离的差异有统计学意义(p = 0.04)。平均SpO2≤89%时，WW降低(p = 0.032)。平均SpO2≤88%时，QMVC下降(p = 0.05)。结论6MWT后，SpO2发生率较高，与GOLD分期无关，仅与到达的距离有关。6MWT后的平均SpO2更敏感，它首先与性能参数有关，其次与肌肉力量有关，最后与股四头肌收缩力量有关。我们发现所研究的去饱和参数与肌肉质量测量之间没有关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revista de Patologia Respiratoria Medicine-Pulmonary and Respiratory Medicine

CiteScore

0.30

自引率

0.00%

发文量

期刊介绍： Revista de Patología Respiratoria is the scientific journal of the Madrilenian Pulmonology and Thoracic Surgery Society (Neumomadrid). It will consider those original articles related to Pulmonology, Thoracic Surgery and all other related sciences for their possible publication. Other types of articles such as reviews, editorials, special articles, scientific letters and letters to the editor are also published in the journal. It is a quarterly Journal that publishes a total of 4 issues, which contain these types of articles to different extents. All publications submitted will always undergo a peer review and a final decision will be made according to comments from the expert reviewers and members of the Editorial Board. The Journal is published both in Spanish and English. Therefore, the submission of manuscripts written in either Spanish or English is welcome.