Angiopoyetina-1 plasmática en el segundo trimestre como predictor del desarrollo de preeclampsia

Abstract

Objective

To establish the usefulness of plasma concentrations of angiopoietin-1 in the second trimester as a predictor of the development of pre-eclampsia.

Material and methods

A prospective and observational study was conducted on 504 nulliparous pregnant women between 17 and 20 weeks gestation who attended the Antenatal Clinic of the Hospital Central Dr. Urquinaona, Maracaibo, Venezuela. An evaluation was made of the general characteristics, plasma angiopoietin-1 concentrations, and prognosis efficacy.

Results

The cases were 41 pregnant women who developed pre-eclampsia (group A), and 463 pregnant women that were considered as controls (group B). No significant differences were found in maternal age, gestational age, and systolic and diastolic blood pressure at the time of the ultrasound evaluation (p = ns). Gestational age at the time of pre-eclampsia diagnosis in group A was 35.0 ± 3.2 weeks. Significant differences were found in the plasma angiopoietin-1 concentrations between patients in group A (11.8 ± 2.8 ng/mL) and patients in group B (5.9 ± 1.7 ng/mL; P < .0001). A cut-off value of 8 ng/mL had an under the curve value of 0.97, a sensitivity of 80.4%, a specificity of 97.4%, a positive predictive value of 73.3%, and a negative predictive value of 98.2%.

Conclusion

Plasma angiopoietin-1 concentrations in the second trimester could predict the development of pre-eclampsia in nulliparous pregnant women without any other concomitant factor.