Lípidos y lipoproteínas en restricción intrauterina del crecimiento con velocimetría Doppler anormal de la arteria umbilical

Abstract

Objective

To compare plasma lipids and lipoproteins concentrations in newborns with intrauterine growth restriction and alterations of umbilical artery end-diastolic velocity.

Material and methods

A study was conducted on pregnant women with a diagnosis of intrauterine growth restriction who attended at Hospital Central Dr. Urquinaona, Maracaibo, Venezuela. The cases were divided into, reversed umbilical artery end-diastolic velocity (group A), absent umbilical artery end-diastolic velocity (group B), and umbilical artery end-diastolic velocity present and positive (group C). Plasma concentrations of cholesterol, triglycerides, and low- and high-density lipoproteins were also measured in newborns.

Results

Reversed umbilical artery end-diastolic velocity was present in 33 cases, with 71 cases of absent umbilical artery end-diastolic velocity, and 146 cases with umbilical artery end-diastolic velocity present. The newborns in groups A and B had significantly higher plasma concentrations of cholesterol and triglycerides compared with group C (p < .05). High-density lipoproteins were significantly lower in group A and B compared with group C (p < .05). There were no significant differences found in low-density lipoproteins between the three groups (p > .05).

Conclusion

Newborns with intrauterine growth restriction and absent or reversed umbilical artery end-diastolic velocity showed significant alterations in plasma lipids and lipoproteins concentrations.