Análisis descriptivo de diversos aspectos podológicos en pacientes con polineuropatía amiloidótica familiar: serie de casos

Abstract

Introduction

Transthyretin family amyloid polyneuropathy also known as Corino Andrade's disease is an autosomal dominant inherited amyloidosis produced by mutations in the Transthyretin protein gene. The most frequent initial clinical symptom is a classic motor sensory syndrome, which starts in the feet and legs and then extends to the arms, trunk and nerves of the skull In Spain, endemic foci have been described in Mallorca and in Valverde del Camino (Huelva). The objective of the present study is to observe the most frequent podiatric disorders that suffer the individuals of this study based on the neuropathy that they suffer, as well as, to evaluate the role of the podiatrist in this condition.

Patients and methods

Preliminary fieldwork was carried out on a group of 12 individuals affected by natural transthyretin family amyloid polyneuropathy from Valverde del Camino (Huelva). A podiatric examination protocol was applied and evaluated different aspects related to this disease. A podological examination protocol was applied and different aspects related to this disease were evaluated.

Results

82% of the first symptoms of the disease perceived by our study group were in the feet. The most relevant results showed that the thermal, tactile, painful, vibratory and pressure sensations in the feet were altered. Achilles reflex was absent in a large percentage of individuals, as well as decreased dorsiflexion.

Discussion

The clinical variability of the disease indicates the relevance of a multidisciplinary approach, in which podiatrists can be key in the early detection and treatment of this condition.