Advances in pharmacological interventions of aging in mice

Abstract

The remarkable breakthroughs in aging research pave the way allowing us to explore potential interventions to slow down aging process, and more importantly, to improve healthiness. Multiple approaches, including pharmacological and non-pharmacological interventions (e.g. caloric restriction, physical exercise), to a great extent, successfully tackle challenges of age-related phenotypic deficits across species. To date, molecular compounds are largely emerging, such as caloric restriction mimetics, NAD⁺ boosters, and senolytics. The use of mouse models is essential, as one of the best tools, to evaluate the potentials of molecules against aging and to provide a translational basis for treating human frailty. Here, we briefly overview present advances on therapeutic interventions against aging in laboratory mouse models and discuss the benefits and pitfalls on their clinical application for anti-aging and aging-related pathologies in humans.