Yahyah Aman , Yumin Qiu , Jun Tao , Evandro F. Fang
{"title":"Therapeutic potential of boosting NAD+ in aging and age-related diseases","authors":"Yahyah Aman , Yumin Qiu , Jun Tao , Evandro F. Fang","doi":"10.1016/j.tma.2018.08.003","DOIUrl":null,"url":null,"abstract":"<div><p>Nicotinamide adenine dinucleotide (NAD<sup>+</sup>) is an essential cofactor in all living cells that is involved in fundamental biological processes. NAD<sup>+</sup> depletion has been associated with hallmarks of aging and may underlie a wide-range of age-related diseases, such as metabolic disorders, cancer and neurodegenerative diseases. Emerging evidence implicates that elevation of NAD<sup>+</sup> levels may slow or even reverse the aspects of aging and also delay the progression of age-related diseases. Here we discuss the roles of NAD<sup>+</sup>-synthesizing and -consuming enzymes in relationships to aging and major age-related diseases. Specifically, we highlight the contribution of NAD<sup>+</sup> depletion to aging and evaluate how boosting NAD<sup>+</sup> levels may emerge as a promising therapeutic strategy to counter aging-associated pathologies and/or accelerated aging.</p></div>","PeriodicalId":36555,"journal":{"name":"Translational Medicine of Aging","volume":"2 ","pages":"Pages 30-37"},"PeriodicalIF":0.0000,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tma.2018.08.003","citationCount":"53","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Translational Medicine of Aging","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468501118300063","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 53
Abstract
Nicotinamide adenine dinucleotide (NAD+) is an essential cofactor in all living cells that is involved in fundamental biological processes. NAD+ depletion has been associated with hallmarks of aging and may underlie a wide-range of age-related diseases, such as metabolic disorders, cancer and neurodegenerative diseases. Emerging evidence implicates that elevation of NAD+ levels may slow or even reverse the aspects of aging and also delay the progression of age-related diseases. Here we discuss the roles of NAD+-synthesizing and -consuming enzymes in relationships to aging and major age-related diseases. Specifically, we highlight the contribution of NAD+ depletion to aging and evaluate how boosting NAD+ levels may emerge as a promising therapeutic strategy to counter aging-associated pathologies and/or accelerated aging.
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