Técnica del ganglio centinela en el cáncer de colon

Q4 Medicine
José Domingo Sardón Ramos, José Errasti Alustiza, Baltasar Cermeño Toral, Eugenia Campo Cigarras, José Antonio Romeo Ramírez, Jaione Sáenz de Ugarte Sobrón, Lorena Reka Mediavilla, María Cuadra Cestafe, Virginia Moreno Nieto, Erika Miranda Serano, Begoña Atares Pueyo
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引用次数: 1

Abstract

Introduction

The study of lymph nodes is the most important prognostic factor in colorectal cancer without metastasis. The sentinel lymph node technique identifies the lymph node that best predicts the patient's lymph node status and allows the performance of techniques of intensive study that improve staging. The aim of this study was to evaluate the efficacy of the sentinel lymph node technique in the staging of colon cancer.

Methods

We performed a prospective study of 45 patients preoperatively diagnosed with colon cancer in stages 0, i and ii. We carried out the sentinel lymph node technique ex vivo and with methylene blue. The sentinel lymph node was studied through multiple sections and immunohistochemical techniques in addition to hematoxylin and eosin staining. We performed a comparison with a control group of 45 patients who were studied through a single section and hematoxylin and eosin staining.

Results

We identified the sentinel lymph node in 98% of the patients, with a false-negative rate of 0. Overstaging was found to occur in 4.8 to 23.8% of the patients. In patients in whom less than 12 lymph nodes were studied, overstaging was between 10.5 and 36.8%.

Conclusions

Study of sentinel lymph nodes carried out ex vivo and with methylene blue predicts the lymph node status of patients with colon cancer. This technique overstages patients to stage iii, who will receive chemotherapy, which could improve their prognosis. The benefit of this technique is greater in patients, in whom less than 12 lymph nodes are studied.

结肠癌的岗哨淋巴结技术
淋巴结的研究是判断结直肠癌有无转移最重要的预后因素。前哨淋巴结技术识别最能预测患者淋巴结状态的淋巴结,并允许强化研究技术的表现,以改善分期。本研究的目的是评估前哨淋巴结技术在结肠癌分期中的疗效。方法对45例术前诊断为0、i、ii期结肠癌患者进行前瞻性研究。我们进行了前哨淋巴结技术离体和亚甲基蓝。前哨淋巴结除苏木精和伊红染色外,还通过多次切片和免疫组织化学技术进行研究。我们通过单个切片和苏木精和伊红染色与对照组的45例患者进行了比较。结果我们在98%的患者中发现前哨淋巴结,假阴性率为0。4.8 ~ 23.8%的患者出现过分期。在小于12个淋巴结的患者中,分期过高的比例在10.5 - 36.8%之间。结论体外和亚甲基蓝对前哨淋巴结的研究可预测结肠癌患者的淋巴结状态。这项技术将患者提前到iii期,他们将接受化疗,这可以改善他们的预后。这项技术的好处是更大的病人,在研究少于12个淋巴结。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Gaceta Medica de Bilbao
Gaceta Medica de Bilbao Medicine-Medicine (all)
CiteScore
0.10
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