Gastrointestinal stromal tumor of the stomach. Case report

Abstract

Gastrointestinal stromal tumors (GISTs) are rare mesenchymal tumors of the alimentary tract. Nowadays GISTs represents 0.1–3% of all gastrointestinal malignancies, making it a diagnostic challenge. Lesions are frequently located in stomach and proximal small intestine but rarely elsewhere in the abdomen. They are believed to result from mutations of proto-oncogenes c-Kit or platelet-derived growth factor receptor alpha polypeptide, this increase tyrosine kinase receptor activity, leading to uncontrolled proliferation of stem cells that differentiate into cells of Cajal. They can occur at any age but predominantly in middle-aged people and in elderly. We report the case of a 28-year-old male presented to our hospital with upper gastrointestinal bleeding, findings in diagnostic image studies suggested a gastric GIST without evidence of metastatic disease; therefore totally tumor excision was performed. Cytologic and inmunohistochemistry analysis confirm diagnosis of GISTs.