Intracholecystic Papillary-tubular Neoplasm (ICPN) of the Gallbladder: A Case Report Focusing on an Unexpected Pathological Finding.

Recent patents on anti-cancer drug discovery Pub Date : 2023-10-25 DOI:10.2174/0115748928256837231012151452

Antonio Pesce, Valentina Sani, Alba Gaban, Nicolò Fabbri, Massimo Tilli, Roberta Gafà, Carlo Vittorio Feo

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Abstract

Background: Intracholecystic papillary neoplasms (ICPNs) represent a rare benign entity characterized by intraluminal polypoid lesions in the gallbladder. The incidence of ICPNs ranges from 0.4% to 0.61% in all gallbladder specimens.

Case presentation: In this report, we present a case of a young Caucasian woman who underwent elective laparoscopic cholecystectomy due to gallbladder polyps. The histological examination revealed the presence of an intracholecystic papillary neoplasm (ICPN) with a tubulopapillary growth pattern, exhibiting gastric morphology and displaying both low and high-grade dysplasia. A thorough review of the existing literature was conducted, with a specific focus on the histological features.

Conclusion: A comprehensive understanding of neoplastic polyps of the gallbladder is still limited. Pathological examination of these lesions is crucial for identifying key features that can influence patient outcomes and survival.

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胆囊内乳头状管肿瘤（ICPN）：一例关注意外病理发现的病例报告。

背景：胆囊内乳头状肿瘤（ICPNs）是一种罕见的良性实体，其特征是胆囊腔内息肉样病变。在所有胆囊标本中，ICPNs的发生率在0.4%至0.61%之间。病例介绍：在本报告中，我们介绍了一例年轻的高加索妇女，她因胆囊息肉接受了选择性腹腔镜胆囊切除术。组织学检查显示，胆囊内乳头状肿瘤（ICPN）具有管乳头状生长模式，表现为胃形态，并表现为低度和高度发育不良。对现有文献进行了全面的回顾，特别关注组织学特征。结论：对胆囊肿瘤性息肉的全面了解仍然有限。这些病变的病理学检查对于确定可能影响患者预后和生存的关键特征至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Recent patents on anti-cancer drug discovery

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