Effect of anodized zirconium implants on early osseointegration process in adult rats: a histological and histomorphometric study.

IF 4.4 3区 医学 Q2 ENGINEERING, BIOMEDICAL
Progress in Biomaterials Pub Date : 2019-12-01 Epub Date: 2019-11-22 DOI:10.1007/s40204-019-00124-0
María Florencia Tano de la Hoz, María Rosa Katunar, Ariel González, Andrea Gomez Sanchez, Alcira Ofelia Díaz, Silvia Ceré
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引用次数: 6

Abstract

Since surface plays a key role in bioactivity, the response of the host to the biomaterial will determine the success or failure of the prosthesis. The purpose of this study is to make an exhaustive analysis of the histological and histochemical characteristics of new bone tissue around Zr implants anodized at 60 V (Zr60) supported by histomorphometric methods in a rat model. Fibrous tissue was observed around the control implants (Zr0) and osteoblasts were identified on the trabeculae close to the implantation site that showed typical cytological characteristics of active secretory cells, regardless of the surface condition. The histomorphometrical analysis revealed a significant increase in cancellous bone volume, trabecular thickness and in trabecular number together with a decrease in trabecular separation facing Zr60. TRAP staining showed that there was a relative increase in the number of osteoclasts for Zr60. In addition, a larger number of osteoclast with a greater number of nuclei were detected in the tibiae for Zr60. This research demonstrated that the new bone microarchitecture in contact with Zr60 is able to improve the early stages of the osseointegration process and consequently the primary stability of implants which is a crucial factor to reduce recovery time for patients.

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阳极氧化锆植入物对成年大鼠早期骨整合过程的影响:一项组织学和组织形态计量学研究。
由于表面在生物活性中起着关键作用,宿主对生物材料的反应将决定假体的成败。本研究的目的是在大鼠模型中用组织形态计量学方法对在60V(Zr60)下阳极氧化的Zr植入物周围的新骨组织的组织学和组织化学特征进行详尽的分析。在对照植入物(Zr0)周围观察到纤维组织,在靠近植入部位的小梁上鉴定出成骨细胞,无论表面状况如何,这些成骨细胞都表现出活性分泌细胞的典型细胞学特征。组织形态计量学分析显示松质骨体积、小梁厚度和小梁数量显著增加,同时面对Zr60的小梁分离减少。TRAP染色显示Zr60的破骨细胞数量相对增加。此外,对于Zr60,在胫骨中检测到具有更多细胞核的大量破骨细胞。这项研究表明,与Zr60接触的新骨微结构能够改善骨整合过程的早期阶段,从而改善植入物的主要稳定性,这是减少患者恢复时间的关键因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Progress in Biomaterials
Progress in Biomaterials MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
9.60
自引率
4.10%
发文量
35
期刊介绍: Progress in Biomaterials is a multidisciplinary, English-language publication of original contributions and reviews concerning studies of the preparation, performance and evaluation of biomaterials; the chemical, physical, biological and mechanical behavior of materials both in vitro and in vivo in areas such as tissue engineering and regenerative medicine, drug delivery and implants where biomaterials play a significant role. Including all areas of: design; preparation; performance and evaluation of nano- and biomaterials in tissue engineering; drug delivery systems; regenerative medicine; implantable medical devices; interaction of cells/stem cells on biomaterials and related applications.
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